【摘要】 目的:分析舌鳞癌的预后相关因素,并为舌鳞癌的治疗方案制定提供临床参考依据。方法:回顾性分析2010年6月～2018年3月期间行外科根治性手术,统一行舌癌原发灶和颈清组织的连续整块切除手术的患者329例。结果:本研究中患者5年生存率为73.01%,局部控制率为84.74%。Cox多因素分析发现年龄(P=0.045 1)、组织病理分级(P<0.000 1)以及临床分期(P=0.004 9)和舌癌患者的5年总生存率密切相关。线性回归多因素分析发现组织病理分级(P=0.000 3)、T分期(P=0.009 7)及淋巴结转移(P=0.040 6)与舌癌患者局部疾病控制密切相关。结论:年龄、组织病理分级以及临床分期是预测舌癌患者不良预后的重要因素,同时组织病理分级、T分期及淋巴结转移与舌癌患者局部疾病控制密切相关。更多还原

【Abstract】 Objective: To analyze the prognostic factors of tongue squamous cell carcinoma(TSCC) and provide a clinical reference for the treatment of TSCC. Methods: 329 patients underwent radical resection of TSCC primary tumor and neck dissection were included in this study. Results: The overall 5-year survival rate was 73.01% and the local control rate was 84.74%. Cox multivariate analysis showed that age(P=0.045 1), histological grade(P<0.000 1) and clinical stage(P=0.004 9) were closely related to the 5-year overall survival rate of the patients with TSCC. Multivariate linear regression analysis showed that histopathological grade(P=0.000 3), T stage(P=0.009 7) and lymph node metastasis(P=0.040 6) was closely related to local disease control in the patients. Conclusion: Age, histological grade and clinical stage are important prognostic factors, the histological grade, T stage and lymph node metastasis are closely related to local disease control in patients with TSCC.更多还原