【摘要】 目的 探讨基于多参数MRI预测鼻咽癌（NPC）Ki-67表达水平的价值。方法 前瞻性收集63例经病理确诊为NPC患者的临床及MRI资料。所有患者治疗前均接受鼻咽部MRI常规平扫加增强、扩散加权成像（DWI）及动脉自旋标记（ASL）扫描。多因素logistic回归分析Ki-67表达水平的独立危险因素。结果 强化程度、血流量最大值(BF_max)及表观扩散系数最小值(ADC_min)是NPC患者Ki-67表达水平的独立危险因素。基于三者建立的预测模型曲线下面积（AUC）为0.920,敏感度为0.792,特异度为0.897。结论 基于常规增强、ASL及DWI组成的多参数MRI能有效预测NPC患者Ki-67表达水平。更多还原

【Abstract】 Objective To explore the value of multi-parameter MRI in predicting the Ki-67 expression level in nasopharyngeal carcinoma（NPC）.Methods The clinical and MRI data of 63 patients with pathologically confirmed NPC were prospectively collected.All patients underwent routine plain and enhanced nasopharyngeal MRI,diffusion weighted imaging（DWI）,and arterial spin labeling（ASL） scans before treatment.Multivariate logistic regression analysis was used to identify the independent risk factors for the Ki-67 expression level.Results The degree of enhancement, the maximum blood flow(BF_max),and the minimum apparent diffusion coefficient(ADC_min) were independent risk factors for the Ki-67 expression level in NPC patients.The area under the curve（AUC） of the prediction model established based on these three factors was 0.920,with a sensitivity of 0.792 and a specificity of 0.897,respectively.Conclusion Multi-parameter MRI based on conventional enhancement, ASL,and DWI can effectively predict the Ki-67 expression level in NPC patients.更多还原