【摘要】 目的 探讨CT引导下一次性肺结节定位针在孤立性肺结节(SPN)应用中安全性与准确性。方法 回顾性选取SPN患者150例，均以CT引导下一次性肺结节定位针定位病灶后接受胸腔镜手术，根据定位准确性分为较好组(n=91)和较差组(n=59)。对定位准确性进行多因素logistic回归分析筛选出定位准确性较差的危险因素。应用模型潜在类别分析比较影响因素分布特征与分布模式的差异。结果 与定位较好组相比，定位较差组在术后病理情况不良及并发症均增加(P<0.05)。年龄、病程、体质量指数(BMI)、吸烟史、饮酒史、病灶直径、结节距胸膜垂直距离、胸壁厚度为定位准确性较差的危险因素(P<0.05)。在定位准确性较差高风险组和低风险组中，均存在2种相互独立的潜在类别分析模型，与定位准确性较差低风险组相比，定位准确性较差高风险组中的“危险因素较多分布”占比较高(P<0.05)。结论 定位准确性的好坏直接影响术后病理情况及并发症的发生概率。更多还原

【Abstract】 Objective To explore the safety and accuracy of the disposable pulmonary nodule localization needle under CT-guided in the application for solitary pulmonary nodule(SPN).Methods A retrospective selection was conducted on 150 patients with SPN.All patients underwent thoracoscopic surgery after the lesions were localized by the disposable pulmonary nodule localization needle under CT-guided.According to the localization accuracy,they were divided into the better localization group(n=91) and the poorer localization group(n=59).Multivariate logistic regression analysis was performed to identify risk factors for poorer localization accuracy.Latent class analysis of the model was applied to compare the differences in the distribution characteristics and patterns of the influencing factors.Results Compared with the better localization group,the poorer localization group had an increase in both adverse postoperative pathological conditions and complications(P<0.05).Age,course of disease,body mass index(BMI),smoking history,drinking history,diameter of the lesion,vertical distance from the nodule to the pleura,and thickness of the chest wall were the risk factors for poorer localization accuracy(P<0.05).In both the high-risk group and the low-risk group with poorer localization accuracy,there were two mutually independent latent class analysis models.Compared with the low-risk group with poorer localization accuracy,the high-risk group exhibited a higher proportion of “more distribution of risk factors”(P<0.05).Conclusion The quality of localization accuracy directly affects the probabilities of postoperative pathological conditions and complications.更多还原