【摘要】 目的 采用静息态功能磁共振成像（rs-fMRI）探讨前庭性偏头痛（VM）患者脑部体素镜像同伦连接（VMHC）改变。方法 前瞻性收集30例VM患者（VM组）及30例健康志愿者（对照组）的rs-fMRI数据。计算所有受试者脑部VMHC值并比较2组间差异。分析VM组差异脑区VMHC值与临床量表评分的相关性。结果 与对照组相比,VM组小脑6区、眶部额下回、脑岛、颞上回以及中央后回的VMHC值均降低[团簇水平家族错误率（FWE）校正,P_体素<0.001,P_团簇<0.05]。VM组中央后回的VMHC值与眩晕残障程度评定量表（DHI）评分呈负相关（r=-0.383,P=0.037）,脑岛的VMHC值与头痛影响测评量表-6（HIT-6）评分呈负相关（r=-0.430,P=0.018）。结论 VM患者部分脑区存在VMHC改变,提示前庭、疼痛、听觉以及情绪相关功能异常。更多还原

【Abstract】 Objective To investigate the brain voxel-mirrored homotopic connectivity（VMHC） alterations in patients with vestibular migraine（VM） by using resting-state functional magnetic resonance imaging（rs-fMRI）.Methods The rs-fMRI data of 30 VM patients（VM group） and 30 healthy volunteers（control group） were prospectively collected.The brain VMHC values in all subjects were calculated and the differences between the two groups were compared.The correlations between VMHC values of significant brain regions and clinical scale scores were analyzed in the VM group.Results Compared with the control group,the VMHC values of the cerebellum region 6,orbital inferior frontal gyrus,insula,superior temporal gyrus and postcentral gyrus in the VM group were all dec reased[cluster-lev el family wise error（FWE） corrected,P_voxel-level<0.001,P_{cluster-level}<0.05].In the VM group,the VMHC values of the postcentral gyrus were negatively correlated with dizziness handicap inventory（DHI） score（r=-0.383,P=0.037）.Additionally,the VMHC values of the insula were negatively correlated with headache impact test-6（HIT-6） score（r=-0.430,P=0.018）.Conclusion VM patients have altered VMHC in certain brain regions,indicating related dysfunctions in vestibule,pain,hearing and emotion.更多还原