【摘要】 目的 研究喉癌中组蛋白去乙酰化酶1(HDAC1)的表达及与其预后的关系。方法 选择75例喉癌患者作为研究对象，采用免疫组化法测定HDAC1表达，随访3年观察其预后情况，分为预后良好组、预后不良组，比较两组HDAC1表达，分析喉癌中HDAC1表达与预后的关系。结果 癌组织内HDAC1表达高于癌旁正常组织(P<0.05)。不同性别、年龄、解剖类型喉癌患者HDAC1表达差异无统计学意义(P>0.05);肿瘤分期Ⅲ～Ⅳ期、低分化、有淋巴结转移的喉癌患者HDAC1表达高于肿瘤分期Ⅰ～Ⅱ期、中高分化、无淋巴结转移的喉癌患者(P<0.05)。75例喉癌患者经规范治疗后随访3年，共16例复发转移，复发转移率为21.33%(16/75),纳入预后不良组；预后不良组喉癌患者HDAC1表达高于预后良好组(P<0.05)。绘制ROC曲线图，结果显示，入院时HDAC1表达预测喉癌患者预后的AUC为0.683。结论 喉癌患者中HDAC1的高表达与预后不良相关，提示HDAC1可能作为喉癌患者预后评估的潜在标志物。更多还原

【Abstract】 Objective To investigate the expression of histone deacetylase 1(HDAC1)in laryngeal carcinoma and its relationship with prognosis.Methods A total of 75 patients with laryngeal cancer were selected as subjects, HDAC1 expression was determined by immunohistochemical method, and the prognosis was observed after 3 years of follow-up.HDAC1 expression was divided into good prognosis group and poor prognosis group, and the relationship between HDAC1 expression and prognosis in the 2 groups was analyzed.Results The HDAC1 expression in cancer tissues was higher than that in adjacent normal tissues(P<0.05).There was no significant difference in HDAC1 expression among patients with different gender, age and anatomical types(P>0.05).HDAC1 expression in laryngeal cancer patients with stage Ⅲ～Ⅳ,low differentiation and lymph node metastasis was higher than that in laryngeal cancer patients with stage Ⅰ～Ⅱ,medium and high differentiation and no lymph node metastasis(P<0.05).The 75 patients with laryngeal cancer were followed up for 3 years after standard treatment, and a total of 16 cases had recurrence and metastasis, the recurrence and metastasis rate was 21.33%(16/75),and they were included in the poor prognosis group.HDAC1 expression in laryngeal cancer patients with poor prognosis was higher than that in good prognosis group(P<0.05).ROC curve was drawn, and the results showed that the AUC of HDAC1 expression in predicting the prognosis of laryngeal cancer patients at admission was 0.683.Conclusion The high expression of HDAC1 in patients with laryngeal cancer is associated with poor prognosis, suggesting that HDAC1 may be a potential marker for prognosis evaluation in patients with laryngeal cancer.更多还原