【摘要】 目的 探讨早期非小细胞肺癌(NSCLC)胸腔镜术后胸腔引流时间延长的影响因素，并构建列线图风险预测模型。方法 回顾性分析，收集108例2021年1月至2023年11月完成胸腔镜肺癌根治术治疗的早期NSCLC患者资料，查阅患者术后胸腔引流时间延长(引流时间≥5 d)的发生情况，同时记录研究所需资料，将胸腔镜术后胸腔引流时间延长的患者纳入延长组，其他纳入未延长组。比较2组资料，建立Logistic回归模型，分析早期NSCLC胸腔镜术后胸腔引流时间延长的影响因素，基于风险因素构建列线图预测模型。结果 108例早期NSCLC患者，胸腔镜术后胸腔引流时间延长32例，占29.63%(32/108)。延长组手术时间长于非延长组，肺叶切除及合并低蛋白血症患者占比高于非延长组(P<0.05)。经构建Logistic回归模型分析发现，手术时间长、肺叶切除、合并低蛋白血症是早期NSCLC胸腔镜术后胸腔引流时间延长的危险因素(OR>1,P<0.05)。基于回归分析结果，构建相关列线图风险预测模型，采用Bootstrap自抽样法和C-index对上述模型进行内部验证(C-index=0.941),列线图的精确度和区分度良好，校准曲线与理想曲线贴合良好。结论 早期NSCLC胸腔镜术后胸腔引流时间延长的危险因素可能为手术时间长、肺叶切除、合并低蛋白血症，据此建立的列线图模型对早期NSCLC胸腔镜术后胸腔引流时间延长的预测效能良好。更多还原

【Abstract】 Objective To explore the influencing factors of prolonged thoracic drainage time after thoracoscopic surgery for early non small cell lung cancer(NSCLC),and to construct a column chart risk prediction model.Methods A retrospective analysis was conducted to collect data from 108 early NSCLC patients who underwent thoracoscopic radical surgery for lung cancer.All patient’s information was complete, and patient information was consulted to record the occurrence of prolonged postoperative thoracic drainage time(drainage time≥5 days)in patients.At the same time, the required research data was recorded.Patients with prolonged postoperative thoracic drainage time after thoracoscopy were included in the extended group, while others were included in the non extended group.The data of the 2 groups were compared, a Logistic regression model was established to analyze the factors affecting the prolonged thoracic drainage time after thoracoscopic surgery in early NSCLC,and a column chart model was built based on the risk factors.Results Among 108 early NSCLC patients, 32 cases(29.63%/108)had prolonged thoracic drainage time after thoracoscopic surgery.The surgery time in the extended group was longer than that in the non extended group, and the proportion of patients with lobectomy and concurrent hypoalbuminemia was higher than that in the non extended group(P<0.05).After constructing a Logistic regression model, it was found that long surgical time, lobectomy, and concurrent hypoalbuminemia were risk factors for prolonged thoracic drainage time after thoracoscopic surgery in early NSCLC(OR>1,P<0.05).Based on the regression analysis results, a relevant column chart risk prediction model was constructed, and the above model was internally validated using Bootstrap self sampling method and C-index(C-index=0.941).The accuracy and discrimination of the column chart were good, and the calibration curve fitted well with the ideal curve.Conclusion The risk factors for prolonged thoracic drainage time after thoracoscopic surgery in early NSCLC may be long surgical time, lobectomy, and concurrent hypoalbuminemia.The column chart model established based on this has good predictive efficacy for prolonged thoracic drainage time after thoracoscopic surgery in early NSCLC.更多还原