【摘要】 目的：探讨基于容量保证通气模式（volumetric guaranteed, VG）下的机械通气与新生儿呼吸窘迫综合征（respiratory distress syndrome, RDS）撤机结局的关系。方法：本研究为单中心前瞻性研究，按照随机数字表法将我院2022年1月至2024年10月期间收治的129例RDS的新生儿分为对照组（接受压力控制通气，n=64）和观察组（接受压力控制通气叠加VG, n=65）。对比两组有创通气时长、总呼吸支持时长、住院时长、动脉血气参数[二氧化碳分压（partial pressure of carbon dioxide, PaCO₂）、pH值、血氧分压（partial pressure of oxygen, PaO₂）、PaO₂/吸入氧浓度（fraction of inspired oxygen, FiO₂）]、撤机时间、拔管失败率、并发症发生率。结果：观察组的有创通气时长、总呼吸支持时长、撤机时间及住院时长短于对照组，拔管失败率、并发症发生率低于对照组（P<0.05）。干预24 h后、干预48 h后，Pa CO₂下降，pH值、PaO₂、PaO₂/FiO₂升高。观察组PaCO₂低于对照组，pH值、PaO₂、PaO₂/FiO₂高于对照组（P<0.05）。结论：基于VG下机械通气可缩短新生儿RDS机械通气时间，改善血气分析指标，减少撤机时间、拔管失败率和并发症风险。更多还原

【Abstract】 Objective: To explore the relationship between mechanical ventilation based on volumetric guaranteed（VG） ventilation mode and weaning outcomes of neonatal respiratory distress syndrome（RDS）. Methods:This study was a single-center prospective study, according to random number table method, 129 neonatal with RDS who were admitted to our hospital from January 2022 to October 2024 were divided into control group（received pressure-controlled ventilation, n=64） and observation group（received pressure-controlled ventilation combined with VG, n=65）. The duration of invasive ventilation, total duration of respiratory support, length of hospital stay,arterial blood gas parameters [partial pressure of carbon dioxide（PaCO₂）, pH value, partial pressure of oxygen（PaO₂）, PaO₂/fraction of inspired oxygen（FiO₂）], weaning time, extubation failure rate and incidence of complications were compared between the two groups. Results: The duration of invasive ventilation, the total duration of respiratory support, the weaning time and the length of hospital stay in the observation group were shorter than those in the control group, and the extubation failure rate and the incidence of complications were lower than those in the control group（P<0.05）. 24 h, 48 h after intervention, PaCO₂ decreased, while pH value, PaO₂ and PaO₂/FiO₂ increased. The Pa CO₂ in the observation group was lower than that in the control group, while the pH value, PaO₂ and Pa O₂/FiO₂ were higher than those in the control group（P<0.05）. Conclusion: Mechanical ventilation based on VG can shorten the mechanical ventilation time of neonatal with RDS, improve blood gas analysis indicators, and reduce weaning time, extubation failure rate and the risk of complications.更多还原