【摘要】 溃疡性结肠炎（ulcerative colitis,UC）是由多因素引发的一种发生于结直肠部位的慢性炎症性肠病，其特征包括肠道菌群失衡、上皮功能障碍和异常黏膜免疫。芳香烃受体（aryl hydrocarbon receptor,AHR）配体是能与AHR直接结合，促进AHR入核并转录调控下游基因的小分子，包括激动剂和拮抗剂。研究表明，饮食中长期缺乏AHR激动剂易导致结肠炎发生。食物及其代谢产物中的AHR激动剂能够通过影响AHR信号传导调控肠上皮和免疫细胞稳态，有效改善结肠炎症。本文总结AHR对UC中肠屏障关键细胞的作用，提出AHR激动剂具有细胞特异性；归纳AHR配体的常见食物来源和代谢方式，以及能够协同增效AHR信号通路的食物成分及机制；解释某些AHR配体作用不稳定的原因，为探索基于饮食的UC干预策略提供了科学依据。更多还原

【Abstract】 Ulcerative colitis(UC) is a chronic inflammatory bowel disease triggered by multiple factors, characterized by gut microbiota dysbiosis, epithelial barrier dysfunction, and abnormal mucosal immunity. Aryl hydrocarbon receptor(AHR) ligands, including agonists and antagonists, are small molecules that directly bind to AHR, promoting its nuclear translocation and transcriptional regulation of downstream genes. Studies have shown that a long-term deficiency of AHR agonists in the diet can increase the risk of UC. The AHR ligands in foods and their metabolites can regulate the homeostasis of intestinal epithelial and immune cells by modulating AHR signaling, thereby alleviating colonic inflammation. This article summarizes the role of AHR in regulating the key cells of the intestinal barrier in UC and proposes that AHR agonists have cellspecific effects. It outlines the common food sources and metabolic pathways of AHR ligands, as well as food components that can synergistically enhance AHR signaling and the underlying mechanisms. The paper also explains the reasons for the unstable effects of certain AHR ligands, providing a scientific basis for exploring diet-based intervention strategies for UC.更多还原