【摘要】 目的 观察振腹疗法对慢性前列腺炎/慢性盆腔疼痛综合征(Chronic prostatitis/Chronic pelvic pain syndrome, CP/CPPS)患者的临床疗效及对其白细胞介素-17(Interleukin-17,IL-17)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)的影响。方法 选取2023年3月—2023年12月北京中医药大学第三附属医院男科、泌尿外科、推拿科门诊收治的CP/CPPS患者44例，按随机数字表法分为对照组和治疗组，每组各22例。对照组予盐酸坦索罗辛缓释胶囊0.2 mg治疗，1次/d;治疗组在对照组治疗的基础上联合振腹疗法，操作20 min,每周治疗3次，隔日1次。治疗4周后，观察比较两组患者美国国立卫生研究院慢性前列腺炎症状积分指数(The national institutes of health chronic prostatitis symptom index, NIH-CPSI)疗效、中医证候疗效及不良反应情况，治疗前后NIH-CPSI评分、中医证候积分、炎性指标(IL-17、TNF-α)。结果 治疗后治疗组总有效率95.45%(21/22)明显高于对照组72.73%(16/22),差异有统计学意义(P<0.05)。治疗后治疗组中医证候总有效率90.91%(20/22)明显高于对照组68.18%(15/22),差异有统计学意义(P<0.05)。治疗后两组患者NIH-CPSI评分均较治疗前降低，差异有统计学意义(P<0.05);且治疗组NIH-CPSI评分较对照组明显降低，差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前降低，差异有统计学意义(P<0.001);且治疗组中医证候积分较对照组明显降低，差异有统计学意义(P<0.05)。治疗后两组患者IL-17、TNF-α水平均较治疗前降低，差异有统计学意义(P<0.05);且治疗组IL-17、TNF-α水平均较对照组明显降低，差异有统计学意义(P<0.05)。治疗期间，两组患者均无明显不良反应发生。结论 振腹疗法联合西药可有效改善CP患者临床症状，其机制可能与抑制血清炎症因子水平、降低炎症反应有关。更多还原

【Abstract】 Objective To investigate the clinical efficacy of abdominal vibration therapy in patients with chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)and its impact on interleukin-17(IL-17)and tumor necrosis factor-α(TNF-α)levels.Methods A total of 44 patients with CP/CPPS admitted to the outpatient clinics of the Department of Andrology, Department of Urology, and Department of Tuina at the Third Affiliated Hospital, Beijing University of Chinese Medicine from March 2023 to December 2023 were selected and randomly divided into the control group and the treatment group, with 22 cases in each group.The control group received tamsulosin hydrochloride extended-release capsules(0.2 mg, once daily),while the treatment group received abdominal vibration therapy in addition to the same medication.The therapy was administered for 20 minutes, three times per week, on alternate days, for four weeks.Clinical efficacy, traditional Chinese medicine(TCM)syndrome efficacy, and the occurrence of adverse reactions were compared.Changes in the national institutes of health chronic prostatitis symptom index(NIH-CPSI)scores, TCM symptom scores, and serum inflammatory markers(IL-17 and TNF-α)were evaluated before and after treatment.Results After treatment, the total effective rate in the treatment group was 95.45%(21/22),significantly higher than 72.73%(16/22)in the control group(P<0.05).The total effective rate of TCM syndrome improvement in the treatment group was 90.91%(20/22),also significantly higher than 68.18%(15/22)in the control group(P<0.05).NIH-CPSI scores in both groups decreased significantly after treatment(P<0.05),with greater reductions observed in the treatment group(P<0.05).TCM syndrome scores also decreased significantly in both groups after treatment(P<0.001),with the treatment group showing significantly lower scores than the control group(P<0.05).Levels of IL-17 and TNF-α significantly decreased in both groups after treatment(P<0.05),with greater reductions observed in the treatment group(P<0.05).No significant adverse reactions occurred in both groups.Conclusions Abdominal vibration therapy can effectively improve clinical symptoms in patients with CP/CPPS.Its mechanism may be related to the suppression of serum inflammatory factors and the reduction of the inflammatory response.更多还原