【摘要】 针刺防治心肌缺血再灌注损伤(MIRI)的机制与其激活神经-内分泌-免疫(NEI)网络密切相关。该网络通过神经递质、激素和免疫因子介导系统间交互,协同调控心脏。通过针刺激发NEI级联反应,在穴位局部产生生物学响应,以NEI网络为枢纽实现系统性调控效应,最终改善MIRI病理进程。聚焦MIRI的针刺干预,分别从神经信号传导、内分泌激素调控和免疫调节3个维度解析其作用路径,并基于NEI网络整体观,阐释针刺多靶点调节MIRI的分子机制,为深入理解其作用原理提供思路。更多还原

【Abstract】 The mechanism by which acupuncture prevents and treats myocardial ischemia reperfusion injury(MIRI) is closely related to its activation of the neuro-endocrine-immune(NEI) network. This network mediates inter-system communication via neurotransmitters, hormones, and immune factors, coordinately regulates cardiac function. Acupuncture triggers NEI cascade reactions, which generates local biological responses at acupoints. Using the NEI network as a hub, acupuncture achieves systemic regulatory effects, ultimately ameliorating the pathological progression of MIRI. This study focuses on the acupuncture intervention for MIRI. It analyzes its pathways of action from three dimensions: neural signaling pathways, endocrine hormonal regulation, and immune modulation. Furthermore, based on the holistic concept of the NEI network, it elucidates the molecular mechanisms underlying acupuncture’s multi-target modulation of MIRI, providing insights for a deeper understanding of its therapeutic principles.更多还原