【摘要】 p120连环蛋白（p120-catenin,p120ctn）是犰狳蛋白家族的重要成员之一，作为血管内皮钙黏蛋白（vascular endothelial cadherin,VE-cadherin）的核心稳定因子，p120ctn在血管发育的全过程中具有多重作用。从新生血管的形成到后续血管完整性的维持，p120ctn的存在不可或缺。p120ctn参与调控脊椎动物胚胎血管的正常发育，促进内皮细胞增殖。同时，p120ctn也有助于黏附连接的维持与重塑，并能够通过改变细胞形态来调节黏附力。本文从血管生成和内皮屏障功能两方面，对p120ctn的研究进展进行综述。更多还原

【Abstract】 p120-catenin(p120ctn) is one of the crucial members of armadillo family, which is well known as a core stabilizing factor for vascular endothelial cadherin(VE-cadherin). Throughout the entire process of vascular development, p120ctn plays multiple roles. From neovascularization to endothelial barrier, the presence of p120ctn is indispensable. It participates in regulating the normal development of vertebrate embryo vasculature and promoting endothelial cell proliferation. Additionally, p120ctn contributes to the maintenance and remodeling of adherens junctions and can modulate adhesion strength by altering cell morphology. This review summarized the latest research progress on p120ctn from neovascular development and endothelial barrier function.更多还原