【摘要】 原发性肝细胞癌(hepatocellular carcinoma, HCC)是目前常见的恶性肿瘤之一，引发HCC的主要危险因素是HBV感染。乙型肝炎病毒X蛋白(hepatitis B virus X protein, HBx)是HBV相关肝细胞癌的关键调节因子，能够促进癌症的发生。许多长链非编码RNA(long non-coding RNA, lncRNA)能够导致HCC的发生，它们的主要功能包括促进HBV复制、上调癌基因或下调肿瘤抑制因子的表达，有些lncRNA还可以直接作为肿瘤抑制因子发挥作用，目前它们已经作为疾病治疗靶点被大量研究。该文将讨论经HBx调节的lncRNA在HBV诱导的HCC中的作用，并对肿瘤发生、发展的机制展开综述。更多还原

【Abstract】 Hepatocellular carcinoma(HCC) is one of the most common malignancies, and the main risk factor for HCC is HBV infection. Hepatitis B virus X protein(HBx) is a key regulator of HBV-associated HCC and can promote tumorigenesis. It has been reported that many long non-coding RNA(lncRNA) contribute to the HCC development, mainly by promoting HBV replication, up-regulating oncogenes expression, or down-regulating the expression of tumor suppressors.Some lncRNA can also act directly as tumor suppressors, which have been extensively studied as disease-treating targets.In this review, we will discuss the role of HBx-regulated lncRNA in HBV-induced HCC and summarize the mechanisms of tumorigenesis and the development of cancer.更多还原