【摘要】 为改善睡眠障碍并研究调制睡眠的神经机制，本研究设计了四种声电多模态刺激模式探究刺激参数对被试睡眠质量与特征脑区响应变化的影响。首先，通过对被试脑电(EEG)数据的溯源分析，提取与睡眠相关的11个脑区内的时间序列；然后，通过功率谱密度(PSD)得到不同脑区在δ、θ、α、σ、β五种频段上的能量变化，并利用主观量表评估被试近一个月的睡眠质量；最后，利用手指敲击实验探究刺激对大脑程序性记忆的影响。结果表明，各模式刺激均对被试程序性记忆无影响，M1与M3优化了被试睡眠期间的情绪调控，降低了嗜睡程度，同时M1激活了睡眠相关脑区，提高了睡眠质量。本研究可为多模态睡眠调制机制提供新的思路。更多还原

【Abstract】 In order to improve the sleep disorders and explore the neural mechanism of sleep regulation, we designed four acoustic with electrical multimodal stimulation modes to explore the influence of stimulation parameters on the sleep quality and response changes of characteristic brain regions of the subjects. Firstly, through traceability analysis of the electroencephalogram(EEG) data of the subjects, time series related to sleep in 11 brain regions were extracted. Then, the energy changes of different brain regions in the five frequency bands of δ, θ, α, σ, and β were obtained through power spectral density(PSD). Meanwhile, the experiment used subjective scales to evaluate the sleep quality of the subjects in the past month. Finally, the finger tapping experiment was used to explore the impact of stimulation on the brain′s programmed memory. The results showed that each mode of stimulation had no effect on the participants′ programmed memory, M1 and M3 optimized the emotional regulation of the subjects during sleep, reduced the degree of sleepiness, and at the same time, M1 activated sleep-related brain regions, improving sleep quality. The research can provide new ideas for multimodal sleep modulation mechanisms.更多还原