【摘要】 目的 探讨男男性行为者（MSM）人群猴痘认知水平及疫苗接种意愿，分析影响疫苗接种意愿的因素。方法 2023年12月-2024年4月，在武汉市3家艾滋病定点医疗机构，采用方便抽样的方法，以电子问卷的形式对MSM人群猴痘相关知识及猴痘疫苗接种意愿开展调查。采用χ~2检验分析不同人口学特征MSM人群的猴痘知识知晓率及猴痘疫苗接种意愿，采用二元logistic回归模型分析影响猴痘疫苗接种意愿的相关因素。结果 共纳入495名MSM，猴痘相关知识总体知晓率为38.2%(189/495)，猴痘疫苗接种意愿率为75.6%(374/495)。多因素分析显示，年龄25～<45岁（OR=0.419,95%CI:0.185～0.947）及45～<65岁（OR=0.392,95%CI:0.155～0.986）MSM接种意愿均显著低于<25岁组；“不担心”（OR=0.282,95%CI:0.148～0.538）及“非常不担心”（OR=0.123,95%CI:0.032～0.475）感染猴痘的MSM接种意愿均显著低于“非常担心”组；认为猴痘“是可以预防”（OR=7.181,95%CI:1.124～45.865）的MSM显著高于认为猴痘“不可预防”组。疫苗犹豫的主要原因包括对疫苗不良反应和保护效力的担忧，对疫苗费用的顾虑。结论 武汉市MSM人群的猴痘认知水平和疫苗接种意愿有较大提升空间。应持续加强猴痘相关知识的普及，针对不同年龄层群体制定干预策略，提高高风险人群对猴痘的认知水平，增加疫苗接种意愿，有效降低猴痘在MSM人群中的传播风险。更多还原

【Abstract】 Objective To investigate monkeypox awareness and vaccination willingness among men who have sex with men(MSM) and to analyze factors influencing vaccination willingness. Methods A cross-sectional survey was conducted among MSM at three designated AIDS clinics in Wuhan, China, between December 2023 and April 2024. Participants were recruited by convenience sampling and completed an electronic questionnaire assessing their monkeypox knowledge and vaccination willingness. Data were analyzed using chi-square tests to compare knowledge awareness and willingness across demographic groups, and binary logistic regression to identify determinants of vaccination willingness. Results A total of 495 MSM were included. The overall monkeypox awareness rate was 38.2%(189/495), and the vaccination willingness rate was 75.6%(374/495). Multivariate analysis showed that MSM aged 25-<45 years(OR=0.419, 95%CI: 0.185-0.947) and 45-<65 years(OR=0.392, 95%CI: 0.155-0.986) were significantly less likely to be vaccinated than those aged <25 years. MSM who were “not worried”(OR=0.282, 95%CI: 0.148-0.538) and “very not worried”(OR=0.123, 95%CI:0.032-0.475) were significantly less likely to receive monkeypox vaccine than those who were “very worried”. MSM who believed monkeypox was “preventable”(OR=7.181, 95%CI:1.124-45.865) were significantly more likely to receive monkeypox vaccine than those who believe it was “unpreventable”. The main reasons for vaccine hesitancy included concerns about vaccine adverse reactions, protective efficacy, and cost. Conclusions There is significant room for improvement in monkeypox awareness and vaccination willingness among MSM in Wuhan. Continued efforts should be made to disseminate monkeypox-related information and develop targeted intervention strategies for different age groups to improve monkeypox awareness among high-risk individuals, increase vaccination willingness, and effectively reduce the risk of monkeypox transmission among MSM.更多还原