【摘要】 目的 研究乳腺X线评估微钙化与乳腺癌发病及其乳腺癌分子生物学预后的关系。方法 选择2022年1月—2024年6月本院收治的乳腺癌患者80例作为研究对象，另选取同期进行健康体检的志愿者80名作为对照组，比较研究组与对照组、不同分子生物学行为组微钙化情况之间的差异。分析ER、PR以及HER-2表达与微钙化病灶以及微钙化局部分布、形态的相关性。结果 研究组患者的微钙化率为42.50%显著高于对照组的82.50%,在微钙化患者中，研究组患者与对照组的微钙化分布、形态之间的差异存在统计学意义(χ~2=17.292,P=0.000),乳腺癌患者不同ER、PR以及HER-2表达情况的微钙化病灶以及微钙化局部分布、形态之间的差异均具有统计学意义(P<0.05),相关性分析结果显示，ER、PR以及HER-2表达与微钙化病灶以及微钙化局部分布、形态呈现显著的正相关。结论 不同ER、PR以及HER-2表达情况下，乳腺癌患者所表现出的微钙化病灶特征存在显著差异。此类差异不仅反映了疾病本身生物学行为，还为临床提供了重要信息，有助于医生制定个体化治疗方案。更多还原

【Abstract】 Objective To investigate the relationship between microcalcifications assessed by breast X-ray and the incidence of breast cancer as well as its molecular biological prognosis.Methods 80 breast cancer patients admitted to our hospital from January 2022 to June 2024 were selected as the subjects of this study, and 80 volunteers undergoing health examinations during the same period were selected as the control group.Differences in microcalcifications between the study and control groups, as well as different molecular biological behavior groups were compared.The correlation between ER,PR,HER-2 expression and the distribution, morphology of microcalcifications was analyzed.Results The microcalcification rate in the study group(42.50%) was significantly higher than that in the control group(82.50%).Among patients with microcalcifications, there were statistically significant differences in the distribution and morphology of microcalcifications between the study and control groups(χ~2=17.292,P=0.000).There were significant differences in microcalcification lesions and local distribution, morphology of microcalcifications among breast cancer patients with different ER,PR,and HER-2 expression(P<0.05).Correlation analysis showed a significant positive correlation between ER,PR,HER-2 expression, and microcalcification lesions, as well as their local distribution and morphology.Conclusions Microcalcification features in breast cancer patients vary significantly depending on ER,PR,and HER-2 expression.Such differences not only reflect the biological behavior of the disease itself but also provide important information for clinical practice, aiding in the formulation of individualized treatment plans.更多还原