【摘要】 黄芪山药粥是以黄芪、山药为主药的经典药膳，具有健脾益气、扶正固本的功效。本文从中医“脾主运化”理论与肠道微生态的现代生物学关联出发，系统阐释黄芪、山药的活性成分及其配伍对肠道菌群结构、代谢产物及宿主免疫功能的调控机制。研究表明，黄芪多糖与山药黏液蛋白通过协同调节肠道菌群代谢（如短链脂肪酸生成）、修复肠屏障完整性及抑制炎症信号通路，发挥了药食同源物质“多成分-多靶点-多途径”的干预优势，为慢性代谢性疾病的预防提供了理论依据。更多还原

【Abstract】 Huangqi Shanyao Congee is a classical medicated diet with Huangqi(Astragali Radix) and Shanyao(Dioscoreae Rhizoma) as the chief medicines, which possesses the effects of strengthening the spleen, benefiting qi, and reinforcing healthy qi to strengthen the body. This paper systematically elucidates the regulatory mechanisms of the active ingredients of Huangqi(Astragali Radix) and Shanyao(Dioscoreae Rhizoma) and their combination on intestinal microbiota composition, metabolic profiles, and host immune functions, based on the Chinese medicine(CM) theory of “the spleen governing transportation and transformation” and modern intestinal microecology. The study demonstrates that Astragalus polysaccharides and Dioscorea mucilage proteins synergistically regulate intestinal microbiota metabolism(e.g., short-chain fatty acids production), enhance intestinal barrier integrity, and suppress inflammatory signaling pathways. These findings highlight the “multi-component, multi-target, and multi-pathway” intervention advantages of food-medicine dual-use substances,providing theoretical basis for preventing chronic metabolic diseases.更多还原