【摘要】 [目的]优化杀菌剂氟茚唑菌胺的合成方法，提高反应收率以及降低生产成本。[方法]以4-氟苯胺和丙酮为起始原料，经缩合、催化氢化、乙酰化、重排和酰胺缩合5步反应合成目标化合物，并对反应条件进行优化。[结果]在优化的反应条件下，本路线总收率为59.6%(以4-氟苯胺计)，产品含量达到98.8%。[结论]此路线原料易得、操作简便、条件温和，适合工业化大规模生产。更多还原

【Abstract】 [Aims] The aim is to optimize the synthesis method of fungicide fluindapyr, improve reaction yield, and reduce the production cost. [Methods] Using 4-fluoroaniline and acetone as the starting materials, the target compound was synthesized by a five-step reaction sequence comprising condensation, catalytic hydrogenation,acetylation, rearrangement and amide condensation, and the reaction conditions were optimized. [Results] Under the optimized reaction conditions, the total yield of this method was 59.6%(based on 4-fluoroaniline), and the purity of the product reached 98.8%. [Conclusions] This method has advantages of readily available materials, simple operation and mild conditions, making it suitable for the industrial large-scale production.更多还原