【摘要】 4-(羟基甲基膦酰基)-2-氧代丁酸作为重要的α-酮酸类化合物，其高效制备是提升L-草铵膦竞争力的核心环节。详细分类并介绍了基于不同中间体的Claisen缩合、酰腈水解、加成重排等反应合成4-(羟基甲基膦酰基)-2-氧代丁酸最新研究进展。对该领域的研究趋势进行了总结，并对未来的研究方向进行了展望，为其后续化学合成提供参考。更多还原

【Abstract】 4-(Hydroxymethylphosphinyl)-2-oxobutanoic acid, as an important α-keto acid compound, plays a crucial role in enhancing the competitiveness of L-glufosinate. This article provided a detailed classification and review of the latest research progress in the synthesis of 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid via various intermediate-based reactions, including Claisen condensation, nitrile hydrolysis, and addition-rearrangement. It also summarized current research trends in the field, offered prospects for future research directions, and provided valuable references for its subsequent chemical synthesis.更多还原