【摘要】 N6-甲基腺苷(N6-methyladenosine, m~6A)作为真核生物RNA上最主要的转录后修饰，在多种生理和病理过程中发挥关键调控作用。随着高通量测序与单碱基分辨率检测技术的迅速发展，越来越多的m~6A修饰相关蛋白及其靶基因在水生动物中被成功鉴定，相应的调控功能与分子机制也逐渐得以阐明。本文系统综述了m~6A修饰在爬行类、两栖类、鱼类、甲壳类、软体动物及棘皮动物等水生动物中的功能及其作用机制，旨在揭示该修饰在进化过程中的功能保守性与物种特异性，并为水生动物的生长发育、抗逆育种及病害防控提供潜在的分子靶标与生物标志物。更多还原

【Abstract】 N6-methyladenosine(m~6A), the predominantly internal epigenetic modification in eukaryotic RNA, plays an important role in a variety of physiological and pathological processes. With the rapid development of high-throughput sequencing and single-base resolution detection technologies, an increasing number of m~6A modification-related proteins and their target genes have been successfully identified in aquatic animals, and the corresponding regulatory functions and molecular mechanisms have gradually been clarified. This review systematically summarized the functions and mechanisms of m~6A modification in aquatic animals such as reptiles, amphibians, fish, crustaceans, mollusks, and echinoderms, which aim to reveal the functional conservation and species specificity of this modification during evolution, and to provide potential molecular targets and biomarkers for the growth and development, stress-resistant breeding, and disease control of aquatic animals.更多还原