【摘要】 脑卒中发病机制复杂，发病后会导致机体产生一系列炎症反应，诱发趋化因子在内的大量细胞因子的产生与聚集。因此，在疾病早期找到与疾病发生发展相关、提示预后的标志物，尽早指导治疗进而以有效改善预后愈发重要。研究了近年来在脑卒中发病机制及预后中关键的趋化因子和趋化因子受体的作用，并重点归纳了可作为提示疾病预后的趋化因子生物标志物，供临床参考。更多还原

【Abstract】 Stroke is the first cause of death and disability in adults in China, and its pathogenesis is complex. After stroke, the body will produce a series of inflammatory reactions, induce the generation and aggregation of a large number of cytokines including chemokines, which is closely related to the development and prognosis of the disease. Therefore, in recent years, it has become increasingly important to find prognostic markers related to the occurrence and development of diseases at an early stage, and guide treatment as soon as possible to effectively improve the prognosis. In this paper, we reviewed the role of chemokines and chemokine receptors in the pathogenesis and prognosis of stroke in recent years, and summarized the chemokine biomarkers that can be used as prognostics for clinical reference.更多还原