【摘要】 [目的]探究罗布麻水提物对小鼠胃肠运动的影响，为罗布麻产品的科学使用提供参考。[方法]用罗布麻水提物进行2倍浓度递增试验、一次性浓度试验及与毒蕈碱型受体（M-受体）激动剂联合用药试验，探究其对小鼠离体小肠段运动的影响；给小鼠灌胃5、25、125 g/L罗布麻水提物或生理盐水，然后再灌胃墨汁，计算肠推进率和均分4段长度小肠的墨汁残留率。[结果]与用药前比较，2倍浓度递增（0.5～8.0 g/L）的罗布麻水提物可降低离体小肠段的收缩张力和收缩幅度；一次性浓度（4.0 g/L）罗布麻水提物给药后极显著（P<0.01）降低肠段收缩张力和收缩幅度，分别为用药前的（74.5±2.2）%和（82.0±2.6）%；罗布麻水提物与M-受体激动剂氯贝胆碱（BCh）联合用药后离体小肠段收缩峰值与用药前峰值百分比[（180.8±6.4）%]极显著（P<0.01）高于台氏液与BCh联合用药[（158.1±4.7）%]。罗布麻水提物灌胃小鼠剂量依赖性降低小鼠肠推进率，且墨汁主要残留在小肠的第3段。[结论]罗布麻水提物对小鼠胃肠运动具有抑制作用，其对小肠运动的抑制作用可能与抑制M-受体无关。更多还原

【Abstract】 [Objective] To investigate the effects of Apocynum venetum water extract(AVWE) on gastrointestinal motility in mice and provide a scientific reference for the rational use of Apocynum venetum-based products. [Methods] A two-fold increasing concentration test, single-concentration test, and combined administration with a muscarinic receptor(M-receptor) agonist were conducted to evaluate the effects of AVWE on isolated small intestinal segments in mice. Mice were intragastrically administered 5, 25, 125 g/L AVWE or saline, followed by ink suspension, to calculate intestinal propulsion rates and ink retention rates in four equally divided segments of the small intestine. [Results] Compared with pre-treatment values, two-fold increasing concentrations of AVWE(0.5-8.0 g/L) could reduce the contractile tension and amplitude of isolated intestine. A single concentration of AVWE(4.0 g/L) highly significantly(P<0.01) decreased contractile tension and amplitude to(74.5±2.2)%and(82.0 ±2.6)% of pre-treatment levels, respectively. The peak contraction percentage of intestine treated with AVWE combined with the M-receptor agonist bethanechol chloride(BCh) [(180.8±6.4)%] was extremely significantly(P<0.01) higher than that with Tyrode’s solution combined with BCh [(158.1±4.7)%]. AVWE administration dose-dependently reduced intestinal propulsion rate, with ink predominantly retained in the third part of the small intestine. [Conclusion] AVWE inhibits gastrointestinal motility in mice, and its suppressive effect on intestinal motility may be independent of M-receptor antagonism.更多还原