【摘要】 男性生殖功能障碍已成为全球性的问题，有8%～12%的育龄夫妇受不孕不育影响，男性精子浓度、总精子数在过去40年中呈现显著下降趋势，降幅超过了50%。男性生殖功能障碍与多种因素相关。环状RNA(circRNA)是一类具有共价闭合环状结构的非编码RNA,参与多种生物过程，包括基因表达调控、蛋白质功能调控和表观遗传调控等。研究表明，不育患者和健康人群睾丸、精液中的circRNA表达存在差异，提示circRNA参与精子发生过程，其表达异常与男性不育存在关联。本文以circRNA的生物学功能为切入点，汇总了circRNA在男性生殖功能障碍中的研究进展。由于保守、特殊的结构和组织特异性，circRNA具有作为新型生物标志物的潜力，为男性生殖功能障碍的临床诊断提供新策略。更多还原

【Abstract】 Male reproductive disorders have emerged as a global issue. Infertility affects 8% to 12% of couples of childbearing age. The sperm concentration and total sperm count of men have shown a significant downward trend over the past four decades, with a decrease of more than 50%. Male reproductive disorders are related to multiple factors. Circular RNA(circRNA) is a type of non-coding RNA with covalently closed circular structures. It is involved in a variety of biological processes, including gene expression regulation, protein function regulation and epigenetic regulation. Studies have shown that there are differences in the expression of circRNA in the testicles and semen between infertile patients and healthy people, suggesting that circRNA is involved in the process of spermatogenesis, and its abnormal expression is associated with male infertility. This review takes the biological functions of circRNA as the starting point and summarizes the research progress of circRNA in male reproductive disorders. CircRNA has the potential to serve as a novel biomarker due to its conservative, special structure and tissue specificity, which provides a new strategy for the clinical diagnosis of male reproductive disorders.更多还原