【摘要】 目的:分析Y染色体AZFc微缺失对卵细胞胞质内单精子注射(ICSI)妊娠结局的影响。方法:选取2016-2023年来院就诊的男方少精子症或无精子症6 765例为研究对象，回顾性分析Y染色体微缺失检测结果，根据纳入、排除标准和倾向性分配1∶2原则，将180例患者纳入研究，其中Y染色体AZFc微缺失且行ICSI助孕的60例患者为试验组，无Y染色体微缺失且行ICSI助孕的患者120例为对照组。比较两组双方基线特征，男方生殖激素5项，实验室胚胎培养指标及妊娠结局。结果:Y染色体微缺失在少精子症和无精子症人群中总体患病率为3.4%。基线特征中的男性年龄、女性年龄、不孕年限、孕次、产次在两组间差异均无显著性(P>0.05);男方生殖激素5项差异均无显著性(P>0.05);胚胎培养过程中除可移植胚胎差异具有显著性(P<0.05)外，其他差异均无显著性(P>0.05);双方妊娠结局指标除早产率有差异(P<0.05),其他指标如临床妊娠率、活产率、流产率、早产率、异位妊娠率等差异均无显著性(P>0.05)。结论:Y染色体AZFc微缺失患者行ICSI助孕对妊娠结局无显著影响，还需要密切随访后代。更多还原

【Abstract】 Objective: To analyze the effect of Y chromosome AZFc microdeletion on pregnancy outcome of intracytoplasmic sperm injection(ICSI). Methods: From 2016 to 2023, 6 765 cases of oligozoospermia in our hospital were selected as the research objects. The results of Y chromosome microdeletion test were retrospectively analyzed. According to the inclusion exclusion criteria and the principle of propensity distribution 1∶2, 180 patients were included in the study. Sixty patients with Y chromosome AZFc microdeletion and ICSI assisted pregnancy were enrolled into the experimental group. The other 120 patients without Y chromosome microdeletion and ICSI assisted pregnancy were included in the control group. Baseline characteristics, five male sex hormones, laboratory embryo culture and pregnancy outcomes were compared between the two groups. Results: There was no significant difference in male age, female age, infertility years, gravidity and parity between the two groups(P>0.05). There was no significant difference in the five sex hormones of men(P>0.05). Except for transplantable embryos(P<0.05), there was no significant difference in other indicators in the process of embryo culture. There was no difference in pregnancy outcome indicators between the two groups except for the preterm birth rate(P<0.05). Conclusion: ICSI assisted pregnancy with Y chromosome AZFc microdeletion has no significant effect on pregnancy outcome. And close follow-up of offspring is required.更多还原