【摘要】 患者，男，63岁，全身红斑脱屑2个月，加重1个月。皮肤科查体：全身泛发红斑、鳞屑，躯干多处片状群集毛囊角化性丘疹。组织病理提示毛发红糠疹。予以阿维A口服联合司库奇尤单抗皮下注射治疗5周，全身皮损未有好转。改为托法替布联合阿维A口服治疗2周后开始好转，4周后显著好转。随访8个月，托法替布和阿维A减量后皮损轻度复发。更多还原

【Abstract】 A 63-year-old male presented with generalized erythema and desquamation for 2 months. Physical examination showed widespread erythema and scales on his whole body, with multiple grouped follicular keratotic papules on his trunk. The histopathological features of the skin lesion were consistent with those of pityriasis rubra pilaris. The patient was initially treated with oral acitretin combined with subcutaneous injections of secukinumab for 5 weeks, however, the disease was not improved. So, a combined treatment of oral tofacitinib and acitretin was used. After 4 weeks, a significant improvement was observed. There was mild recurrence of skin lesions after the dosage reduction of tofacitinib and acitretin at the 8-month follow-up.更多还原