【摘要】 Paget样网状细胞增生症是一种罕见的皮肤T细胞淋巴瘤，临床表现不具有特异性，容易误诊。本文报道1例，患者，男，39岁，因右足跖斑块、渗出1年就诊。病理检查见较多单一核细胞移入表皮，真皮浅层较多单一淋巴样细胞、嗜酸性粒细胞浸润，细胞核大、深染。免疫组化示CD3、 CD2、CD8等多个抗体阳性，Ki-67表皮内阳性细胞约60%～70%。淋巴结病理检查示呈淋巴组织反应性增生改变。给予患者口服阿维A、注射人α1b干扰素及浅层X线照射等治疗3个月后病情完全缓解。更多还原

【Abstract】 Pagetoid reticulosis is a rare cutaneous T-cell lymphoma with non-specific clinical manifestations and is easily misdiagnosed. This paper reports a case of a 39-year-old male patient presented with plaque and exudation on his right planta for one year. Pathological examination of the lesion showed large number of mononuclear cells migrated into the epidermis, and there was infiltration of a large number of mononuclear lymphoid cells and eosinophils in the superficial dermis. Immunohistochemical staining showed CD3, CD2, CD8 and other antibodies were positive, and about 60%-70% cells were positive for Ki-67 in the epidermis. Pathological examination of the right inguinal lymph node showed reactive proliferation of lymphoid tissue. The patient was treated with oral acitretin, recombinant human interferon-alpha1b injection and superficial X-rayradiotherapy, and achieved complete remission after 3 months of treatment.更多还原