【摘要】 肌少症是老年人重要的健康问题，特征为骨骼肌质量、力量与躯体功能的进行性丧失。研究表明，细胞凋亡的异常激活是肌少症的核心病理机制之一。本文系统阐述细胞凋亡在肌少症发生发展中的作用机制，总结了氧化应激、炎症反应、营养代谢失衡、激素水平变化等因素对细胞凋亡的影响，以及相关研究方法，旨在为进一步深入了解肌少症的发病机制及研发新的治疗策略提供参考。更多还原

【Abstract】 Sarcopenia is a significant health issue among older adults, characterized by the progressive decline of skeletal muscle mass, strength, and physical function.Studies have shown that abnormal activation of apoptosis serves as a key pathological mechanism in the development of sarcopenia.This review systematically examines the role of apoptosis in the progression of sarcopenia, addressing the effects of oxidative stress, inflammation, nutritional and metabolic imbalances, and hormonal changes on apoptotic pathways.Relevant research methodologies are also introduced.The aim of this paper is to provide a theoretical foundation for a deeper understanding of the pathogenesis of sarcopenia and to support the development of novel therapeutic interventions.更多还原