【摘要】 肺癌是近年来全球癌症中发病率最高的恶性肿瘤，目前临床治疗正面临耐药性这一严峻挑战，亟待开发新的应对策略。铁死亡是一种铁依赖性的非凋亡形式细胞死亡方式，其发生与System X_c~--GPX4通路抗氧化防御功能受损、脂质过氧化物积累及细胞内铁代谢紊乱。研究表明，在放疗、化疗、靶向治疗及免疫治疗等多个肺癌治疗领域，诱导铁死亡能够显著增强肿瘤细胞对常规治疗的敏感性，进而逆转耐药表型。目前，部分铁死亡相关药物及新型递送系统已进入临床试验阶段。此外，新型天然铁死亡激动剂的发现及其作用靶点的不断阐明，也为肺癌治疗提供了新的研究方向与策略。更多还原

【Abstract】 Lung cancer has become the most prevalent malignant tumor among all cancers worldwide in recent years. Currently, clinical treatment is facing a severe challenge of drug resistance, and there is an urgent need to develop new strategies to address this issue. Ferroptosis is a form of iron-dependent non-apoptotic cell death, which mainly involves the impairment of the antioxidant defense function of the system X_c~--GPX4 pathway, the accumulation of lipid peroxidation, and the disorder of intracellular iron metabolism. Studies have shown that inducing ferroptosis can significantly enhance the sensitivity of tumor cells to conventional treatments in multiple lung cancer treatment fields, including radiotherapy, chemotherapy, targeted therapy, and immunotherapy, thereby reversing drug resistance. Currently, some ferroptosis-related drugs and novel delivery systems have entered the clinical trial stage. In addition, the discovery of new natural ferroptosis agonists and the continuous clarification of their target sites have also provided new research directions and strategies for lung cancer treatment.更多还原