肌少症分项指标与腹膜透析患者临床预后的相关性分析

【摘要】 目的 分析腹膜透析（PD）患者肌少症分项指标与临床预后的相关性。方法 选择2023年3～6月PD患者287例，根据肌少症的诊断标准将患者分为低握力组与正常握力组，低步速组正常步速组。采用单因素及多因素Cox回归分析各组与生存率和技术治疗生存率的相关性。结果 低握力组患者生存率和技术治疗生存率均低于正常握力组（P<0.001），低步速组患者生存率和技术治疗生存率均低于正常步速组（P<0.05）。多因素Cox回归分析显示，低握力组有更高的死亡风险（P=0.013）和技术治疗失败风险（P=0.016）。结论 低握力和低步速与PD患者的预后相关，低握力是PD患者全因死亡和技术治疗失败的预测指标。更多还原

【Abstract】 Objective To analyze the correlation between individual indicators of sarcopenia and clinical outcomes in peritoneal dialysis(PD)patients. Methods A total of 287 PD patients from March to June 2023 were enrolled and categorized into a low handgrip strength group vs. normal handgrip strength group, and a low gait speed group vs. normal gait speed group based on sarcopenia diagnostic criteria. Univariate and multivariate Cox regression analyses were performed to assess the association between these groups and patient survival as well as technique survival. Results The low handgrip strength group exhibited significantly lower survival and technique survival rates compared to the normal handgrip strength group(P<0.001). Similarly, the low gait speed group showed reduced survival and technique survival rates compared to the normal gait speed group(P<0.05). Multivariate Cox regression analysis revealed that low handgrip strength was associated with a higher risk of all-cause mortality(P=0.013)and technique failure(P=0.016). Conclusion Low handgrip strength and low gait speed are correlated with adverse clinical outcomes in PD patients. Low handgrip strength serves as an independent predictor of all-cause mortality and technique failure in this population.更多还原