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钇-90选择性内放射治疗肝癌的过去、现在与未来

Yttrium-90 selective internal radiation therapy on liver cancer: the past, the present, and the future

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【作者】 马婧嶔张林泓杨敏捷蔡加彬方颖刘嵘瞿旭东刘凌晓颜志平

【Author】 MA Jingqin;ZHANG Linhong;YANG Minjie;CAI Jiabin;FANG Ying;LIU Rong;QU Xudong;LIU Lingxiao;YAN Zhiping;Department of Interventional Radiology, Zhongshan Hospital, Fudan University;Shanghai Institution of Medical Imaging;National Clinical Research Center for Interventional Medicine;Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University;Department of Gastroenterology, Zhongshan Hospital, Fudan University;

【通讯作者】 颜志平;

【机构】 复旦大学附属中山医院介入治疗科上海市影像医学研究所国家放射与治疗医学临床研究中心复旦大学附属中山医院肝胆肿瘤和肝移植外科复旦大学附属中山医院消化科

【摘要】 钇-90选择性内放射治疗(Yttrium-90 selective internal radiation therapy,90Y-SIRT)是一种通过将放射性微球精准输送至肿瘤动脉血管床,利用β射线对肿瘤组织进行局部高剂量放射治疗的技术。该技术已在不可手术的原发性肝癌及转移性肝癌患者中展现出显著疗效。本文系统综述了90Y-SIRT在肝癌治疗中的发展历程和临床应用现状,并展望其未来发展方向。

【Abstract】 Yttrium-90 selective internal radiation therapy(90Y-SIRT) is a treatment technique that delivers radioactive microspheres precisely to the arterial vascular bed of neoplasms, utilizing beta radiation to administer a high local dose of radiation to the neoplasm tissues. This technology has demonstrated significant efficacy in patients with unresectable pirmary liver cancers and liver metastases. This article systematically reviews the development history and clinical application status of 90Y-SIRT in the treatment of liver cancer, and looks forward to future development directions.

【基金】 国家自然科学基金(82302323);上海市科学技术委员会基金(22ZR1460800)~~
  • 【文献出处】 中国临床医学 ,Chinese Journal of Clinical Medicine , 编辑部邮箱 ,2025年01期
  • 【分类号】R735.7;R730.55
  • 【下载频次】272
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