【摘要】 t(8;21)型急性髓系白血病(AML)是AML中常见的细胞遗传学亚型，以AML1基因和ETO基因重排产生AML1-ETO融合基因为基本特征。近年来，随着该领域基础及临床探索的不断深入，t(8;21)型AML在基因调控、白血病细胞表型特征、协同基因突变、临床异质性等方面的研究均取得新的突破。文章拟就t(8;21)型AML发病机制新进展进行阐述，为临床治疗提供新思路。更多还原

【Abstract】 t(8; 21) acute myeloid leukemia(AML) is a common cytogenetic subtype of AML, which is characterized by the rearrangement of the AML1 gene and the ETO gene and the formation of the AML1-ETO fusion gene. Recent advances in both basic and clinical research have significantly enhanced our understanding of the mechanisms associated with t(8; 21) AML, including the gene regulation, phenotypic characteristics of leukemia cells, the presence of secondary cytogenetic mutations, and the clinical heterogeneity observed in patients. This article reviews the latest developments in the pathogenesis of t(8; 21) AML, aiming to provide valuable insights into clinical treatment strategies.更多还原