【摘要】 目的 探究肥胖儿童血清25-羟维生素D[25(OH)D]水平对其糖脂代谢的影响。方法 选取2023年6月至2024年6月在江西省儿童医院诊断为儿童单纯性肥胖并糖脂代谢异常的7～14岁患儿101例作为研究对象，应用随机数字表法将其分为观察组（n=51）和对照组（n=50）。观察组给予维生素D3补充治疗，2组均接受营养师减重期饮食指导联合运动管理。比较2组治疗前后的体重指数（BMI）、血清25(OH)D水平和糖脂代谢指标，并分析治疗前血清25(OH)D水平与BMI和糖脂代谢指标的相关性。结果 治疗前，患儿血清25(OH)D水平与空腹胰岛素水平（FINS）、胰岛素抵抗指数（HOMA-IR）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）呈负相关，与高密度脂蛋白胆固醇（HDL-C）呈正相关（均P <0.05）。治疗后，观察组BMI、FINS、HOMA-IR、TG、TC和LDL-C水平显著低于对照组，而血清25(OH)D和HDL-C水平显著高于对照组（均P <0.05）。结论 肥胖儿童血清25(OH)D水平与其糖脂代谢指标有相关性，单纯性肥胖儿童在饮食联合运动干预的基础上口服维生素D3治疗，有利于其糖脂代谢的改善。更多还原

【Abstract】 Objective To investigate the impact of serum 25-hydroxyvitamin D(25(OH)D) levels on glucose and lipid metabolism in children with obesity. Methods A cohort of 101 children aged 7–14 years diagnosed with simple obesity and glucose/lipid metabolic abnormalities at Jiangxi Provincial Children’s Hospital(June 2023–June 2024) was randomized via a random number table into an observation group(n=51, receiving vitamin D3 supplementation) and a control group(n=50). Both groups underwent dietitian-guided weight-loss dietary interventions combined with exercise management. Body mass index(BMI), serum 25(OH)D levels, and glucose/lipid metabolic parameters were compared preand post-intervention, with correlations analyzed between baseline 25(OH)D levels and metabolic indices. Results Pretreatment serum 25(OH)D levels inversely correlated with fasting insulin(FINS), homeostasis model assessment of insulin resistance(HOMA-IR),triglycerides(TG), total cholesterol(TC), and low-density lipoprotein cholesterol(LDL-C),while positively correlating with high-density lipoprotein cholesterol(HDL-C)(all P <0.05). Post-treatment, the observation group exhibited significantly lower BMI, FINS,HOMA-IR, TG, TC, and LDL-C levels, alongside higher 25(OH)D and HDL-C levels compared to controls(all P < 0.05). Conclusion Serum 25(OH)D levels demonstrate significant correlations with glucose/lipid metabolic profiles in obese children. Adjunctive vitamin D3 supplementation to standard lifestyle interventions may facilitate improvement of metabolic dysregulation in pediatric simple obesity.更多还原