【摘要】 目的:探究童年创伤与精神分裂症患者临床特征之间的相关性。方法:40例急性发作期的精神分裂症患者(精神分裂症组)和40名对照者(对照组),在精神分裂症组入院时以及药物治疗4周后使用阳性和阴性症状量表(positive and negative syndrome scale, PANSS)评估精神症状严重程度。精神分裂症组病情稳定后、对照组在入组时使用童年创伤问卷(childhood trauma questionnaire, CTQ)评定童年创伤情况。结果:精神分裂症组CTQ总分及躯体虐待、性虐待评分显著高于对照组。在精神分裂症组中，CTQ总分及情感忽视、躯体虐待、躯体忽视评分与PANSS阴性分呈正相关；各类童年创伤均与PANSS阳性分不存在相关性。结论:精神分裂症患者存在更加严重的童年创伤，其童年创伤水平主要与患者的阴性症状严重程度存在正相关性。更多还原

【Abstract】 Objective: To investigate the correlation between childhood trauma and the clinical features of schizophrenia patients. Method:This study included 40 patients in an acute episode of schizophrenia(schizophrenia group) and 40 controllers(control group). The severity of psychiatric symptoms in the schizophrenia group was assessed using the positive and negative syndrome scale(PANSS) at admission and after 4 weeks of medication.The childhood trauma questionnaire(CTQ) was used to evaluate childhood trauma in the schizophrenia group once their condition stabilized, and in the control group at the time of enrollment. Results:The total CTQ score, physical abuse, and sexual abuse scores were significantly higher in the schizophrenia group than in the control group.Within the schizophrenia group, there was a positive correlation between the total CTQ score and scores for emotional neglect, physical abuse, and physical neglect with the negative symptoms on the PANSS score.However, there was no correlation between any type of childhood trauma and the positive symptoms on the PANSS score. Conclusion:Patients with schizophrenia have more severe childhood trauma, and the level of childhood trauma is positively correlated mainly with the severity of negative symptoms in these patients.更多还原