【摘要】 近年来，随着环境的污染增加，内外源性刺激可导致机体生物分子发生氧化损伤。核因子红系2相关因子2(nuclear factor erythroid 2-related factor 2,NRF2)作为应对氧化损伤的核心转录因子，通过诱导各种抗氧化因子的表达维持细胞氧化还原稳态。鼻腔作为呼吸道的“门户”常伴随着氧化应激(oxidative stress, OS)的损伤从而诱导变应性鼻炎(allergic rhinitis, AR)的发生，最近的研究揭示了NRF2信号通路与AR发生机制的一些关联，NRF2的活化为AR提供一种潜在的保护作用，并且一些天然的NRF2激活剂也在临床试验研究中展现出治疗潜力，因此本文简要综述NRF2与AR的关系，以期为AR的治疗提供一种新的治疗靶点及思路。更多还原

【Abstract】 In recent years, with the increase in environmental pollution, organisms are exposed to more internal and external oxidative stress factors than ever before.Nuclear factor erythroid 2-related factor 2(nuclear factor erythroid 2-related factor 2,NRF2),as a core transcription factor in response to oxidative stress, maintains cellular redox homeostasis by inducing the expression of various antioxidant factors.The nasal cavity, as the “gateway” of the respiratory tract, is often accompanied by oxidative stress(oxidative stress, OS)damage, leading to the occurrence of allergic rhinitis(allergic rhinitis, AR).Recent studies have revealed some associations between the NRF2 signaling pathway and the mechanism of AR development.Activation of NRF2 provides a potential protective effect against AR,and some natural NRF2 activators have shown therapeutic potential in clinical experiments.Therefore, this article briefly reviews the relationship between NRF2 and AR,aiming to provide a new therapeutic target and perspective for the treatment of AR.更多还原