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种植体周炎在鼠类实验模型构建的研究进展

Research progress in the construction of murine experimental model of peri-implantitis

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【作者】 孙雨欣; 施斌; 吴涛;

【Author】 Sun Yuxin;Shi Bin;Wu Tao;State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University;Department of Dental Implantology, School and Hospital of Stomatology, Wuhan University;Center for Prosthodontics and Implant Dentistry, Optics Valley Branch, School and Hospital of Stomatology, Wuhan University;

【通讯作者】 吴涛;

【机构】 口颌系统重建与再生全国重点实验室口腔生物医学教育部重点实验室口腔医学湖北省重点实验室武汉大学口腔医(学)院; 武汉大学口腔医院种植科; 武汉大学口腔医院光谷院区种植与修复中心;

【摘要】 种植体周炎是口腔种植修复最棘手的并发症,也是直接导致种植体失败的主要原因。成功构建相关动物实验模型是研究种植体周炎发病机制的重要工具。本综述从实验动物的选择、建模方法、建模时间、建模结局指标评价及建模成功率等方面总结了近年来对种植体周炎鼠类实验模型构建的研究进展,旨在为种植体周炎的动物模型构建提供更好的参考和帮助。

【Abstract】 Peri-implantitis is one of the most intractable complications in dental implant treatment, which is also the key factor for implant failure. The construction of relevant animal experimental models that can accurately simulate the pathological features of peri-implantitis is crucial for in-depth exploration of its pathogenesis. This review systematically collates the research progress in recent years on the establishment of murine experimental models of peri-implantitis. The content encompasses the scientific selection of experimental animals, the application of innovative modeling methods, modeling time, the accurate evaluation of modeling outcome indicators, and an in-depth analysis of key factors such as success rate. The aim is to provide more comprehensive and accurate references for researchers in this field.

【关键词】 种植体周炎; 鼠类; 动物实验模型;
【Key words】 Peri-implantitis; Murine; Animal model;
  • 【文献出处】 中国口腔种植学杂志 ,Chinese Journal of Oral Implantology , 编辑部邮箱 ,2025年03期
  • 【分类号】R783.6;R-332
  • 【下载频次】17
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