【摘要】 目的 探讨IGF-1和IGFBP-3在儿童肥胖症中的表达变化及诊断价值。方法 血液样本和对应的临床信息来源于2023年12月至2024年3月期间就诊于昆明市儿童医院的人群，设置对照组（健康儿童；n=115）和研究组（肥胖症儿童；n=86）。采用ELISA法检测两组血清中IGF-1和IGFBP-3的水平。收集两组的临床资料，分析IGF-1和IGFBP-3与临床资料的相关性及在儿童肥胖症中的诊断价值。结果 相较于对照组，研究组中体重和BMI显著增加（P <0.001）,IGF-1和IGFBP-3显著降低（P <0.05）。IGF-1水平与总胆固醇、甘油三酯、载脂蛋白B和胰岛素抵抗指数呈现负相关（P <0.05），与载脂蛋白A和空腹胰岛素呈现正相关（P <0.05）;IGFBP-3表现出相反的模式（P <0.05）。ROC诊断曲线显示，IGF-1和IGFBP-3的曲线下面积为0.598和0.665。结论 IGF-1和IGFBP-3在儿童肥胖症中低表达，并且与肥胖指标相关，具有一定的诊断价值。更多还原

【Abstract】 Objective To explore the expression changes of IGF-1 and IGFBP-3 in childhood obesity and their diagnostic value. Methods Blood samples and corresponding clinical information were collected from patients attending Kunming Children’s Hospital from December 2023 and March 2024,and were divided into a control group(healthy children; n = 115) and a study group(obese children; n = 86). Serum levels of IGF-1 and IGFBP-3 in both groups were measured by using ELISA. Clinical data from both groups were analyzed to assess the correlation between IGF-1 and IGFBP-3 and clinical information, as well as their diagnostic value in childhood obesity.Results Compared to the control group,the study group exhibited a significant increase in weight and BMI(P <0.001) while IGF-1 and IGFBP-3 levels were significantly lower(P < 0.05). IGF-1 levels exhibited a negative correlation with total cholesterol,triglycerides,apolipoprotein B,and insulin resistance index(P < 0.05),and a positive correlation with apolipoprotein A and fasting insulin(P < 0.05); IGFBP-3 displayed the opposite pattern(P< 0.05). ROC diagnostic curves indicated that the area under the curve for IGF-1 and IGFBP-3 was 0.598 and 0.665,respectively. Conclusion IGF-1 and IGFBP-3 are expressed at low levels in childhood obesity and are associated with obesity indicators,demonstrating certain diagnostic value.更多还原