【摘要】 目的 分析成人金黄色葡萄球菌血流感染患者的临床特征以及住院死亡相关的危险因素，为临床治疗和预防干预提供依据。方法 回顾性收集2016年1月至2023年12月间，某院通过血培养确诊为金黄色葡萄球菌血流感染的成人住院患者的临床资料。将患者按照住院期间是否发生死亡分为病例组和对照组，采用二元logistic回归分析方法确定影响患者预后的独立危险因素。结果 共纳入233例金黄色葡萄球菌血流感染病例，多因素logistic回归分析显示年龄≥70岁(OR=4.725、95%CI：1.228～18.173、P=0.024)、糖尿病(OR=8.161、95%CI：1.954～34.086、P=0.004)、Charlson合并症指数≥5(OR=7.672、95%CI：1.901～30.963、P=0.004)、医院感染(OR=7.853、95%CI：1.588～38.832、P=0.012)、快速Pitt菌血症评分(qPitt)≥2(OR=23.189、95%CI：4.461～120.552、P<0.001)为金黄色葡萄球菌血流感染患者死亡的独立危险因素，而血管导管相关性感染来源(OR=0.051、95%CI：0.005～0.579、P=0.016)与死亡率呈负相关。结论 高龄、糖尿病、高Charlson合并症指数、医院感染和高qPitt评分为影响金黄色葡萄球菌血流感染患者预后的独立危险因素，对此类患者应做好管理，及时去除可根除的病灶与更好的预后相关。更多还原

【Abstract】 Objective To investigate the clinical characteristics and prognostic factors of Staphylococcus aureus bloodstream infections in adult patients for improving clinical treatment and identifying potential interventions.Methods Clinical data of inpatients diagnosed with S.aureus bloodstream infection confirmed by blood culture in a hospital from January 2016 to December 2023 were retrospectively reviewed.The data included patient age,gender,history of hospital admission,department of admission,underlying diseases,primary infection,quick Pitt bacteremia score (qPitt),invasive treatment,empirical anti-infective treatment,and treatment outcomes.Patients were assigned to case group or control group according to whether they died in hospital in order to identify the prognostic factors of patient outcomes.Binary logistic regression analysis was used to identify independent prognostic factors.Results A total of 233 cases of S.aureus bacteremia were identified.Multivariate logistic regression analysis showed that age ≥ 70 years old (OR=4.725,95% CI:1.228-18.173,P=0.024),diabetes mellitus (OR=8.161,95% CI:1.954-34.086,P=0.004),Charlson comorbidity index (CCI) ≥ 5 (OR=7.672,95% CI:1.901-30.963,P=0.004),hospital infection (OR=7.853,95% CI:1.588-38.832,P=0.012),and qPitt ≥ 2 (OR=23.189,95% CI:4.461-120.552,P < 0.001) were independent prognostic factors for poor outcome of patients with S.aureus bacteremia,while catheter-associated infection (OR=0.051,95% CI:0.005-0.579,P=0.016) was negatively correlated with mortality.Conclusions Advanced age,diabetes mellitus,high CCI,hospital infection,and high qPitt were independent prognostic factors for poor outcomes of patients with S.aureus bacteremia.The patients should be well managed by timely removal of eradicable lesions to improve patient outcomes.更多还原