【摘要】 目的：大豆是一种含有丰富异黄酮的食品，对糖尿病、心血管疾病、骨质疏松症、肥胖症和相关疾病都有缓解作用，为了进一步筛选活性物质对人体健康的有益作用，我们进行了网络药理学研究。方法：采用了网络药理学及分子对接，从分子方面更深入地找到契合的活性成分。结果：染料木素、大豆苷元、黄豆黄素被预测为大豆的抗氧化的核心活性成分。TNF、PTGS2和HSP90AA1则是大豆治疗抗氧化的关键靶点。GO和KEGG富集分析展示了相关通路，表明氧化应激与癌症、糖尿病及其并发症密切相关。结论：大豆可能对多种疾病具有更有效的预防作用，该研究还为植物活性物质在促进人类健康方面提供了方法和思路。更多还原

【Abstract】 Objective: Soybean(SB), an isoflavone-rich food, has been found to offer relief from diabetes, cardiovascular disease, osteoporosis, obesity and related diseases. To further screen the active substances, we conducted the present study. Methods: Network pharmacology and molecular docking are used to find the fitting active ingredient in greater depth from the molecular side. Results: genistein, daidzein and glycitein were the core antioxidant components of SB. In addition, TNF, PTGS2, EGFR and HSP90AA1 were identified as the key targets of SB therapeutic antioxidants. Relevant pathways were demonstrated by Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses, indicating that oxidative stress was strongly associated with cancer, diabetes and their complications. Conclusion: This suggested that SB from both origins might have a more effective preventive effect on various diseases. Overall, this paper provides valuable methods and insights for the material basis research of similar functional foods.更多还原