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LSD1通过调控FOXO3和线粒体自噬参与卵巢储备的建立和维持（英文）

LSD1 modulates ovarian reserve establishment by modifying FOXO3 and mitophagy-related genes

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【作者】秦韶刚；朱子健；朱天华；林怡；何美娜；赵庭；高萌；林琳；鲍奕冰；张景雯；刘龙萍；王建斌；夏国良；王凤超；周波；王超；

【Author】 Shaogang Qin;Zijian Zhu;Tianhua Zhu;Yi Lin;Meina He;Ting Zhao;Meng Gao;Yibing Bao;Lin Lin;Jingwen Zhang;Longping Liu;Jianbin Wang;Guoliang Xia;Fengchao Wang;Bo Zhou;Chao Wang;State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University;State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital;Tai Kang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University;Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Department of Physiology, College of Basic Medicine, Guizhou Medical University;School of Life Sciences, Tsinghua University;Transgenic Animal Center, National Institute of Biological Sciences;

【通讯作者】王凤超;周波;王超;

【机构】 State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University； State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital； Tai Kang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University； Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Department of Physiology, College of Basic Medicine, Guizhou Medical University； School of Life Sciences, Tsinghua University； Transgenic Animal Center, National Institute of Biological Sciences；

【摘要】 <正>Primordial follicles, the only reproductive resource in females,are the most prevalent and enduring follicle type in the ovary.These follicles have a remarkable lifespan, extending up to 50 years in humans [1]. In female mammals, primordial follicles are formed around birth, with the large majority entering a dormant state immediately upon formation, constituting a dormant follicle pool[2].更多还原

【关键词】卵巢储备； FOXO3； LSD1； ovary； follicle； primordial；英文；自噬； immediately； entering；

【基金】 supported by the National Key Research & Developmental Program of China (2023YFD1300501, 2024YFD1301001, 2022YFC2703803, 2018YFC1003700, and 2018YFC1003801);the National Natural Science Foundation of China (32371167, 32071132, 31872792, 32270904, and 32070839);the Innovative Project of State Key Laboratory of Animal Biotech Breeding (2024SKLAB 1-1);the 2115 Talent Development Program of China Agricultural University

【文献出处】 Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,2025年23期

【分类号】R339.22
【下载频次】14

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