【摘要】 <正>As the second most abundant element on the Earth,silicon is widely used in materials science,medicinal chemistry,and organic synthesis [1].Especially in drug discovery,increasing attention has been paid to the"silicon-carbon switch"strategy in optimizing lead molecules,as silicon can be considered as a carbon isostere due to the similarity in their chemical properties.The replacement of carbon atoms in bioactive molecules with silicon atoms can often result in higher activities compared to their non-silylated counterparts [2].However,the study of the application of enantioenriched silacyclohexanes possessing silicon stereogenic centers in medicinal chemistry is rare,due to the limited methods for their enantioselective synthesis.更多还原