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细胞内氯离子在新型冠状病毒肺炎中的关键调控作用:发病机制及潜在治疗靶点（英文）

Pivotal roles of intracellular Cl~- in COVID-19:pathogenesis and therapeutic targets

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【Author】 Su Qu;Lei Chen;Jie Sheng;Xiao-Chun Hou;Wen-Liang Zhou;Nan-Shan Zhong;Yi-Lin Zhang;School of Life Sciences, Sun Yat-sen University;State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University;Guangzhou National Laboratory,Bio-land;Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes, Sun Yat-sen University;

【通讯作者】周文良;钟南山;张艺林;

【机构】 School of Life Sciences, Sun Yat-sen University； State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University； Guangzhou National Laboratory,Bio-land； Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes, Sun Yat-sen University；

【摘要】 <正>Cl^- has long been recognized as a potent buffer of membrane potential, with changes in intracellular Cl^- concentrations playing crucial physiological roles in cells via electrical signaling. While intracellular second messengers such as Ca²⁺ and c AMP have been extensively studied, Cl^- has received comparatively less attention.However, recent advances have highlighted the significance of intracellular Cl^- signaling in regulating cellular physiological function.更多还原

【关键词】冠状病毒肺炎； intracellular； physiological； signaling；氯离子；靶点；发病机制； potent；英文； regulating；

【基金】 supported by the Major Project of Guangzhou National Laboratory (GZNL2023A02001);the Guangdong Science and Technology Department (2023B1212060028);the China Postdoctoral Science Foundation (2024M760657);the Guangzhou Institute of Respiratory Health Open Project Funds provided by China Evergrande Group (2020GIRHHMS13);the Zhongnanshan Medical Foundation of Guangdong Province (ZNSA-2020012)

【文献出处】 Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,2025年13期

【分类号】R563.1
【下载频次】10

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