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基于间充质干细胞治疗自身免疫性肝炎的研究进展
Research progress in the treatment of autoimmune hepatitis based on mesenchymal stem cells
【摘要】 自身免疫性肝炎(AIH)是一种自身免疫性肝脏疾病,近年来发病率呈上升趋势。间充质干细胞(MSC)及基于MSC的治疗策略在AIH治疗中展现出较好应用前景。该文综述了基于MSC治疗AIH的研究进展,梳理了AIH的定义及分型、发病机制、治疗现状,MSC及其外泌体治疗AIH的作用及机制,以及基于MSC的其他疗法,旨在为AIH治疗策略研究提供参考。
【Abstract】 Autoimmune hepatitis(AIH)is an autoimmune liver disease that is getting increasingly prevalent. Notably,mesenchymal stem cells(MSCs)and MSC-based therapeutic strategies promise wide applications in the treatment of AIH.This paper reviews the treatments for AIH based on MSCs by outlining the definition,classification,pathogenesis and its current treatments of AIH,the role and mechanism of MSCs,their extracellular vesicles in treating AIH as well as other therapies based on MSCs. This study is intended to provide references for the development of AIH treatment strategies.
【Key words】 autoimmune hepatitis; mesenchymal stem cell; exosome; cell therapy; non-cellular therapy;
- 【文献出处】 军事医学 ,Military Medical Sciences , 编辑部邮箱 ,2025年12期
- 【分类号】R575.1
- 【下载频次】26