【摘要】 目的:调查代谢相关脂肪性肝病(MAFLD)患者发生幽门螺杆菌(Hp)感染的危险因素,并对MAFLD患者Hp感染风险预测模型进行构建及验证。方法:选取2023年8月至2023年11月于河南省郑州市某三甲医院进行健康体检的445例体检者为本次研究对象。采用Logistic回归分析MAFLD患者Hp感染的危险因素并构建预测模型,绘制ROC曲线、DCA曲线,结合Hosmer-Lemeshow检验对模型进行评价与验证。结果:445例MAFLD患者中,Hp感染阳性组248例(55.73%),阴性组197例(44.27%)。Logistic回归分析结果显示:性别、年龄、BMI、TG、LDL-C和UA是导致MAFLD患者Hp感染的危险因素(P<0.05)。由ROC曲线计算出预测模型AUC为0.855(95%CI0.819～0.890),灵敏度为81.9%,特异度为76.1%,最大约登指数为0.580,诊断值为0.515。Hosmer-Lemeshow拟合优度检验中,得到χ~2=7.914,P=0.442(P>0.05)。结论:构建的MAFLD患者Hp感染风险预测模型具有较好预测效能。更多还原

【Abstract】 Objective:To investigate the risk factors for the development of Helicobacter pylori(Hp)infection in patients with metabolic associated fatty liver disease(MAFLD),and to construct and validate a predictive model for the risk of Hp infection in patients with MAFLD.Methods:445 cases of medical checkups who underwent health checkups in a tertiary hospital in Zhengzhou City,Henan Province from August 2023 to November 2023 were selected as the subjects of this study.Logistic regression was used to analyse the risk factors of Hp infection in MAFLD patients and construct a prediction model,ROC curves and DCA curves were plotted,and the model was evaluated and validated by combining the HosmerLemeshow test.Results:Of the 445 MAFLD patients,248(55.73%) were in the Hp infection positive group and 197(44.27%) were in the negative group.Logistic regression analysis showed that gender,age,BMI,TG,LDL-C,and UA were the risk factors for Hp infection in patients with MAFLD(P<0.05).The AUC of the prediction model was calculated from the ROC curve as 0.855(95%CI0.819-0.890),sensitivity as 81.9%,specificity as 76.1%,maximal Jordon’s index as 0.580,and the diagnostic value as 0.515.In the Hosmer-Lemeshow goodness-of-fit test,χ~2=7.914,P=0.442(P>0.05).Conclusion:The constructed model for predicting the risk of Hp infection in MAFLD patients has a good predictive efficacy.更多还原