【摘要】 目的:对育龄期女性体检人群子宫平滑肌瘤与焦虑抑郁情绪的相关性进行研究,探讨子宫肌瘤患病风险与焦虑抑郁情绪的关系。方法:选取2023年4月至2024年2月在青岛大学附属医院健康管理中心行健康体检的育龄期女性体检者719例,收集体检者的一般资料、妇科超声结果、广泛性焦虑量表(GAD-7)及抑郁自评量表(PHQ-9),对有、无子宫肌瘤的女性体检者的GAD-7、PHQ-9分数进行比较,对有焦虑、抑郁状态的育龄期女性体检者子宫肌瘤的患病率进行比较,探讨焦虑抑郁情绪对育龄期女性中子宫平滑肌瘤发病的影响。结果:719名受试者中,有子宫肌瘤患者共152例,子宫肌瘤患病率为21.3%(152/719)。子宫肌瘤组的广泛性焦虑症状(GAD-7)评分高于对照组(4[3,7]分vs.4[2,7]分;Z=-3.14,P<0.001),差异有统计学意义。子宫肌瘤组的抑郁症状(PHQ-9)评分也高于对照组(5[3,8]分vs.4[2,7]分;Z=-3.30,P<0.001),差异有统计学意义。焦虑人群子宫肌瘤的患病率高于非焦虑人群子宫肌瘤的患病率,差异有统计学意义(OR=1.46,95%CI 1.02～2.09,P<0.05),抑郁人群子宫肌瘤的患病率高于非抑郁人群子宫肌瘤的患病率,差异有统计学意义(OR=1.53,95%CI 1.06～2.20,P<0.05)。无论是以子宫肌瘤最大直径还是以数目(单发/多发)进行分组,不同组间体检者的GAD-7评分与PHQ-9评分差异均无统计学意义(均P>0.05)。结论:子宫肌瘤的患病率与焦虑抑郁症状相关,焦虑抑郁情绪可能增加育龄期女性子宫肌瘤患病风险。更多还原

【Abstract】 Objective:To study the correlation between uterine leiomyoma and anxiety and depression in women of childbearing age,and to explore the relationship between the risk of uterine fibroids and anxiety and depression.Methods:A total of 719 women of childbearing age who underwent health check-ups in the Health Management Center of the Affiliated Hospital of Qingdao University from April 2023 to February 2024 were enrolled,and the general data,gynecological ultrasound results,Generalized Anxiety Scale(GAD-7) and Depression Self-Rating Scale(PHQ-9) were collected to study the correlation between the prevalence of uterine leiomyoma and anxiety and depression in women of childbearing age,and to explore the effect of anxiety and depression on the incidence of uterine leiomyoma in women of childbearing age.Results:Among the 719subjects,a total of 152 were diagnosed with uterine fibroids,resulting in a prevalence rate of 21.3%(152/719).The Generalized Anxiety Disorder-7(GAD-7) score was significantly higher in the uterine fibroid group compared to the control group(4[3,7] points vs.4[2,7] points;Z=-3.14,P<0.001).Similarly,the Patient Health Questionnaire-9(PHQ-9) score for depressive symptoms was also significantly higher in the uterine fibroid group(5[3,8] points vs.4[2,7] points;Z=-3.30,P<0.001).The prevalence of uterine fibroids was significantly higher in the anxious population compared to the non-anxious population(OR=1.46,95%CI1.02-2.09,P<0.05).Likewise,the prevalence was significantly higher in the depressed population compared to the non-depressed population(OR=1.53,95%CI 1.06-2.20,P<0.05).However,when the participants were grouped based on the maximum diameter of the largest fibroid or the number of fibroids(single/multiple),no statistically significant differences were observed in GAD-7 or PHQ-9 scores between any of the subgroups(all P>0.05).Conclusion:The prevalence of uterine fibroids is related to anxiety and depression symptoms,and anxiety and depression may increase the risk of uterine fibroids in women of childbearing age.更多还原