【摘要】 目的 探讨磁示踪技术用于肺结节定位的可行性。方法 自行设计用于肺结节定位的示踪磁体及配套穿刺器械。在离体肺中初步验证操作的可行性后，以4只比格犬为动物模型，在X射线引导下对右肺上叶假定病灶利用自行设计的示踪磁体和穿刺器械进行穿刺定位，随后开胸对定位效果进行观察和评估。记录示踪磁体置入所需的操作时间、穿刺部位有无出血、示踪磁体有无移位、开胸后病灶定位时间等指标。结果 4只比格犬均成功在X射线引导下于右肺上叶假定病灶旁穿刺置入2枚示踪磁体，磁体顺利相吸固定。示踪磁体中位置入操作时间5 min(4～7 min)，置入过程顺利，穿刺部位无出血。开胸后利用卵圆钳便捷地探寻到示踪磁体所在位置，实现了对肺小结节的精准定位，中位定位时间13 s(10～17 s)，整个过程中示踪磁体无移位。结论 磁示踪技术用于肺结节定位操作简单、定位精准可靠，进一步优化操作流程，该技术有望用于临床。更多还原

【Abstract】 Objective To investigate the feasibility of magnetic tracer technique for locating pulmonary nodules.Methods A tracer magnet and a matching puncture instrument were designed by ourselves for locating pulmonary nodules. After preliminarily verifying the feasibility of the operation in the isolated lung, four beagle dogs were used as animal models to perform puncture localization of the assumed lesions in the upper lobe of the right lung under the guidance of X-ray by using self-designed tracer magnets and puncture instruments, and the positioning effect was observed and evaluated after thorax opening. The operation time required for the tracer magnet implantation, whether there is bleeding at the puncture site, whether the tracer magnet is displaced, and the positioning time of pulmonary nodules after thorax opening were recorded.Results Two tracer magnets were successfully inserted into the upper lobe of the right lung under X-ray guidance in four beagle dogs, and the magnets were successfully attracted and fixed. The median insertion time of the tracer magnet was 5 minutes(4 to 7 minutes), and the insertion process was smooth without bleeding at the puncture site. After thorax opening, oval forceps were used to conveniently locate the location of the tracer magnet, achieving accurate positioning of pulmonary nodules with a median positioning time of 13 seconds(10 to 17 seconds), and the tracer magnet did not shift during the whole process.Conclusion The magnetic tracer technique is simple to operate and pricise for localization of pulmonary nodules. With further optimization of the operation process, this technique is expected to be applied in clinic.更多还原