【摘要】 目的：通过文献计量学方法分析MRI在脑卒中领域应用的前100篇高被引论文，旨在探讨MRI在脑卒中研究中的应用现状、热点及前沿趋势。方法：检索Web of Science Core Collection(WoSCC)数据库建库至2024年2月2日有关MRI和脑卒中相关文献，纳入前100篇被引频次最高的文献。采用VOSviewer和CiteSpace软件对发文量、国家（地区）和机构、国际合作、共引参考文献、共现关键词和突发关键词进行分析。结果：100篇文献发表在1991—2020年，展现出明显的发表趋势波动，其中2003年发文量最高，整体遵循“驼峰曲线”模式，2020年文献年度被引频次达顶峰。100篇共784位作者，依据赖普斯定律有65位核心作者，其中Warach和Parker在作者合作网络中居核心地位。哈佛大学以11篇文献发表量领先，匹兹堡大学等7个机构并列第2。共同发表文献的国家分布分析显示，美国以显著的发文量和合作网络密度在MRI和脑卒中研究领域保持领先地位和国际影响力。CiteSpace软件的双图叠加功能揭示了医学、生物学、免疫学等领域间的高互引频率和密切关联性。通过关键词共现网络分析，揭示了神经病理学、神经影像学技术应用，以及认知功能与康复为当前神经科学研究和临床应用的三大主题，展现了神经影像学技术在理解大脑功能、诊疗神经系统疾病和促进神经功能恢复中的核心作用。结论：MRI技术在脑卒中研究中的应用呈上升趋势，尤其在脑卒中的诊断、疗效评估及神经损伤和修复机制的个性化、客观和精准分析方面。研究重点包括静息态、任务态MRI与PET-CT等技术的结合应用，以及多学科交叉的创新研究和新技术的应用。综合分析揭示了脑卒中领域内MRI应用的研究热点和前沿趋势，以及医学、生物学与神经科学之间的密切联系，为深入理解大脑功能、疾病机制及其治疗提供了新的视角和工具。更多还原

【Abstract】 Objective:By analyzing the top 100 highly cited papers in the field of stroke MRI research using bibliometric methods,to explore the current state,hotspots and frontier trends of MRI in the context of stroke studies. Methods:The papers related to MRI and stroke in the Web of Science Core Collection(WoSCC) database up to February 2,2024,were retrieved,and the 100 most frequently cited papers were included. Tools such as VOSviewer and CiteSpace were used for analyzing publication amount,country and institution distribution,international collaborations,co-cited references,co-occurring keywords,and emerging keywords. Results:The top 100 highly cited papers were published between 1991 and 2020,showing significant publication trend fluctuations with the highest amount in 2003 and following a bimodal distribution pattern,peaking in annual citation frequency in 2020. A total of 784 authors were involved,with 65 core authors identified according to Lotka’s law,among which Warach and Parker held central positions in the author collaboration network. Harvard University led with 11 publications,followed by seven institutions tied for second place including University of Pittsburgh. The analysis of the distribution of countries co-publishing showed the United States maintaining a leading position and international influence in MRI and stroke research with significant publication amount and collaboration network density. The dual-map overlay function of CiteSpace software revealed high citation frequency and close associations between fields such as medicine,biology,and immunology. Through co-occurrence keywords network analysis,three major themes in current neuroscience research and clinical application were unveiled as neuropathology,neuroimaging technology application,and cognitive function and rehabilitation,showcasing the central role of neuroimaging technology in understanding brain function,diagnosing and treating neurological diseases,and promoting neurological recovery. Conclusions:MRI technology is on an upward trend in stroke research,especially in the diagnosis of stroke,assessment of therapeutic efficacy,and personalized,objective,and precise analysis of neural injury and repair mechanisms. Research focuses include the combined application of resting-state,task-state MRI with PET-CT technologies,and the innovative studies and application of new technologies across multidisciplinary fields. Through a comprehensive analysis of highly cited literature,this study reveals the research hotspots and frontier trends in the application of MRI within the stroke field,providing important references for future research directions. Additionally,the study highlights the importance of interdisciplinary knowledge flow,particularly the close connection between medicine,biology,and neuroscience,offering new perspectives and tools for a deeper understanding of brain function,disease mechanisms,and their treatment.更多还原