【摘要】 Poly(C)-结合蛋白1(PCBP1)是一种多功能RNA结合蛋白，参与基因转录，选择性修饰、翻译及铁代谢调节等过程。本文通过对PCBP1相关疾病如膀胱癌、头颈癌等的研究报道，探讨PCBP1抑制铁死亡的途径。PCBP1可以减少细胞内亚铁含量抑制铁死亡，包括抑制铁蛋白自噬，促进铁离子向铁蛋白或铁依赖性酶转移，稳定细胞内不稳定铁池及促进[2Fe-2S]簇生成; PCBP1还可以减少脂质过氧化物的生成，提高细胞对氧化应激的抵抗力来降低细胞内活性氧水平，从而抑制铁死亡。更多还原

【Abstract】 Poly( C)-binding protein 1( PCBP1) is a multifunctional RNA-binding protein involved in a series of processes such as gene transcription,selective modification,translation and regulation of iron metabolism. This paper explores the pathway through which PCBP1 inhibits ferroptosis during the research on PCBP1-related diseases,such as bladder cancer and head and neck cancer. PCBP1 can reduce the intracellular ferrous iron content to inhibit ferroptosis through the mechanisms like inhibiting ferritinophagy,promoting the transfer of iron ions to ferritin or iron-dependent enzymes,stabilizing the labile iron pool within cells and facilitating the formation of[2 Fe-2S]clusters. PCBP1 can also reduce the generation of lipid peroxides and enhance the resistance to oxidative stress thus to reduce the level of intracellular reactive oxygen thereby inhibiting ferroptosis.更多还原