【摘要】 跨膜蛋白基因家族(TMEM)指一类编码跨膜蛋白质的基因家族。TMEM基因家族是通过影响血管生成的主要信号通路，影响肿瘤细胞和血管内皮细胞之间的相互作用，调控VEGF及其受体VEGFR的表达或功能，从而影响肿瘤的血管生成。此外，TMEM基因家族调控组蛋白翻译后修饰等机制影响肿瘤的发生发展，TMEM蛋白翻译后修饰形式包括磷酸化、糖基化、乙酰化、棕榈酰化等。对TMEM基因家族在肿瘤发生发展中作用的机制研究帮助人们确定更加精准的靶向治疗策略。更多还原

【Abstract】 The transmembrane protein gene family(TMEM) refers to a group of genes that encode trans-membrane proteins. The TMEM family influences tumor angiogenesis by affecting key signaling pathways involved in angiogenesis, modulating the interactions between tumor cells and endothelial cells and regulating the expression or function of VEGF and its receptor VEGFR. Thereby it may have impact on tumor blood vessel formation. Additionally, the TMEM family regulates mechanisms such as post-translational modifications of histone, which also play a role in tumor initiation and progression. Post-translational modifications of TMEM proteins including phosphorylation, glycosylation, acetylation and palmitoylation. TMEM family contributes to tumorigenesis and may identify some novo targets used in precise medical treatment.更多还原