【摘要】 目的：观察“俞募配穴、脏腑同调”推拿法治疗肝郁气滞型广泛性焦虑症(generalized anxiety disorder, GAD)的临床疗效及其对患者血清神经递质的影响。方法：将100例肝郁气滞型GAD患者随机分为对照组和观察组，每组各50例，其中对照组脱落3例、观察组脱落2例。对照组口服枸橼酸坦度螺酮片治疗，观察组在对照组基础上给予“俞募配穴、脏腑同调”推拿法治疗，2组患者均治疗40 d。比较2组患者治疗前后汉密尔顿焦虑量表(HAMA)评分，世界卫生组织生存质量测定量表(WHOQOL-100)社会、生理、心理功能评分变化，评价其疗效，比较2组患者治疗前后血清5-羟色胺(5-HT)、γ-氨基丁酸(GABA)、谷氨酸(Glu)含量变化，并记录不良反应。结果：治疗后，2组患者HAMA评分，WHOQOL-100社会、生理、心理功能评分，血清5-HT、GABA、Glu含量与治疗前比较，均有改善(P<0.05),且观察组各评分及血清5-HT、GABA、Glu改善程度均优于对照组(P<0.05);观察组有效率为87.5%,优于对照组的80.9%(P<0.05)。结论：“俞募配穴、脏腑同调”推拿法可有效缓解肝郁气滞型GAD患者临床症状，恢复患者社会、生理、心理功能，并能调节患者血清5-HT、GABA、Glu水平。更多还原

【Abstract】 Objective: To observe the clinical efficacy of the tuina therapy based on "Shu-Mu Combination, Zang-Fu Coordination" in the treatment of generalized anxiety disorder(GAD) of liver depression and qi stagnation type, and its influence on serum neurotransmitters. Methods: A total of 100 GAD patients of liver depression and qi stagnation type were randomly divided into a control group and an observation group, with 50 cases in each group. Among them, 3 cases dropped out in the control group and 2 cases in the observation group. The control group was treated with tandospirone citrate tablets orally, while the observation group was given additional tuina therapy of "Shu-Mu Combination, Zang-Fu Coordination" on the basis of the control group. Both groups received treatment for 40 days. The Hamilton Anxiety Scale(HAMA) scores, and the changes in social, physical, and psychological function scores of the World Health Organization Quality of Life Assessment Scale(WHOQOL-100) before and after treatment were compared between the two groups to evaluate the therapeutic efficacy; the changes in serum levels of 5-hydroxytryptamine(5-HT), γ-aminobutyric acid(GABA), and glutamate(Glu) before and after treatment were compared, and adverse reactions were recorded. Results: After treatment, compared with pre-treatment, both groups showed significant improvements in HAMA scores, social, physical, and psychological function scores of WHOQOL-100, and serum levels of 5-HT, GABA and Glu(all P < 0.05), and the improvement degrees of the above scores and serum neurotransmitter levels in the observation group were significantly superior to those in the control group(all P<0.05). The total effective rate of the observation group was 87.5%, which was significantly higher than 80.9% of the control group(P<0.05). Conclusion: The tuina therapy of "Shu-Mu Combination, Zang-Fu Coordination" can effectively alleviate the clinical symptoms of GAD patients of liver depression and qi stagnation type, restore their social, physical, and psychological functions, and regulate the serum levels of 5-HT, GABA and Glu.更多还原