【摘要】 目的 探讨肥胖型多囊卵巢综合征(PCOS)不孕症患者血清铁代谢指标、miR-29a、血管活性肠肽(VIP)的变化及其临床意义。方法 选取PCOS不孕症患者130例，按照是否肥胖分为肥胖组和非肥胖组；按照随访结果，肥胖组分为促排妊娠成功组和失败组，或者妊娠结局不良组和良好组。比较各组血清铁蛋白、miR-29a、VIP水平，采用ROC曲线分析铁蛋白、miR-29a及VIP的预测价值。结果 肥胖组铁蛋白、miR-29a高于非肥胖组，VIP低于非肥胖组(P<0.05)。失败组铁蛋白、miR-29a高于成功组，VIP低于成功组(P<0.05)。不良组铁蛋白、miR-29a高于良好组，VIP低于良好组(P<0.05)。铁蛋白、miR-29a及VIP对促排妊娠失败具有良好的预测价值，铁蛋白、miR-29a对不良妊娠结局具有良好的预测价值(P<0.05)。结论 PCOS不孕症患者血清铁蛋白、miR-29a升高，VIP降低，且与促排妊娠、妊娠结局有明显关系。更多还原

【Abstract】 Aim To investigate the changes and clinical significance of serum iron metabolism indexes, miR-29a and vasoactive intestinal peptide(VIP) in obese polycystic ovary syndrome(PCOS) infertility patients. Methods We selected 130 PCOS infertility patients and divided them into obese and non-obese groups according to BMI. The obese group was further divided into successful ovulation induction pregnancy group and failure group, or poor pregnancy outcome group and favorable outcome group based on follow-up results. Serum ferritin, miR-29a and VIP levels were compared among groups. Receiver operating characteristic(ROC) curve analysis was performed to evaluate the predictive value of ferritin, miR-29a and VIP. Results The obese group showed higher ferritin and miR-29a levels but lower VIP level compared with the non-obese group(P<0.05). The failure group had higher ferritin and miR-29a levels but lower VIP level compared with the success group(P<0.05). The poor outcome group demonstrated higher ferritin and miR-29a levels but lower VIP level compared with the favorable outcome group(P<0.05). Ferritin, miR-29a and VIP showed good predictive value for ovulation induction failure, while ferritin and miR-29a exhibited good predictive value for poor pregnancy outcomes(P<0.05). Conclusion Serum ferritin and miR-29a levels increase while VIP level decreases in PCOS infertility patients, which significantly associate with ovulation induction pregnancy and pregnancy outcomes.更多还原