【摘要】 磷-32(³²P)是一种发射β射线的医用放射性同位素，在治疗真性红细胞增多症、皮肤病、血管瘤及缓解骨转移疼痛等方面具有独特疗效。研究型核反应堆是实现³²P规模化制备的重要设施。本工作首先介绍了³²P的应用及其反应堆制备现状，基于精细燃耗计算程序对利用研究堆辐照生产³²P的转换特性和产额进行了计算分析。结果表明，高通量堆采用活化法生产³²P比其它一般中子通量水平的研究堆更具优势，通过32S（n, p）³²P途径可制备得到更高比活度的无载体³²P。本工作的研究结果可为研究堆辐照生产³²P提供技术参考。计划后续进一步开展高通量堆生产³²P辐照方案优化研究。更多还原

【Abstract】 Phosphorus-32(³²P), a beta-emitting medical radioisotope, exhibits unique therapeutic efficacy in treating polycythemia vera, dermatological conditions, hemangiomas, and alleviating bone metastasis pain. Research reactors serve as critical facilities for the industrial scale production of ³²P. This paper first introduces the applications of ³²P and the current status of its reactor-based production. Utilizing a sophisticated burnup calculation code, the conversion characteristics and yield of³²P produced via irradiation in research reactors were computationally analyzed. The results demonstrate that high flux reactors offer significant advantages over research reactors with typical neutron flux levels for producing ³²P via the neutron capture method. The 32S（n, p）³²P reaction pathway enables the production of carrier-free ³²P with higher specific activity. The findings of this study provide technical references for ³²P production through research reactor irradiation. Subsequent research will further optimize the irradiation schemes for ³²P production in high flux reactors.更多还原